Association of End Point Definition and Randomized Clinical Trial Duration in Clinical Trials of Schizophrenia Medications.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.1596
Abstract: Importance Facilitating the development of safe and effective medications for schizophrenia is a public health imperative. Objectives To evaluate the association of shortening randomized clinical trial (RCT) duration with the modification of the Positive and… read more here.
Keywords: clinical trial; week; trial; treatment ... See more keywords
The efficacy of cariprazine in negative symptoms of schizophrenia: Post hoc analyses of PANSS individual items and PANSS-derived factors
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DOI: 10.1016/j.eurpsy.2019.01.015
Abstract: Abstract Background: Negative symptoms in schizophrenia are heterogeneous and multidimensional; effective treatments are lacking. Cariprazine, a dopamine D3-preferring D3/D2 receptor partial agonist and serotonin 5-HT1A receptor partial agonist, was significantly more effective than risperidone in… read more here.
Keywords: post hoc; negative symptoms; symptoms schizophrenia; panss derived ... See more keywords
Early Antipsychotic Non-response as a Predictor of Non-response and Non-remission in Adolescents With Psychosis Treated With Aripiprazole or Quetiapine: Results From the TEA Trial.
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DOI: 10.1016/j.jaac.2021.11.032
Abstract: OBJECTIVE In youth with first-episode psychosis, we evaluated 1) whether early-non-response to antipsychotics predicts non-response and non-remission; 2) patient and illness characteristics as outcome predictors; and 3) the response prediction of the Positive and Negative… read more here.
Keywords: response; non response; panss; remission ... See more keywords
Rasch analysis of the PANSS negative subscale and exploration of negative symptom trajectories in first-episode schizophrenia – data from the OPTiMiSE trial
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DOI: 10.1016/j.psychres.2020.112970
Abstract: The observed heterogeneity in negative symptom treatment response may be partly attributable to inadequate measurement tools or limitations in methods of analysis. Previous Item Response Theory models of the Positive and Negative Syndrome Scale (PANSS)… read more here.
Keywords: optimise trial; symptom; negative symptom; symptom trajectories ... See more keywords
M23. ALTERATION OF REGIONAL CEREBRAL BLOOD FLOW MEASURED BY ARTERIAL SPIN LABELING IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA
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DOI: 10.1093/schbul/sbaa030.335
Abstract: Abstract Background Approximately 30% of patients with schizophrenia do not respond to antipsychotics, which is called treatment-resistant schizophrenia (TRS). A recent systematic review showed decreased regional cerebral blood flow (rCBF) in the cerebral cortex and… read more here.
Keywords: schizophrenia; rcbf; treatment; trs ... See more keywords
M47. AKATHISIA AND ATYPICAL ANTIPSYCHOTICS: EXPLORING ASSOCIATIONS TO SUICIDALITY AND AGITATION
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DOI: 10.1093/schbul/sbaa030.359
Abstract: Abstract Background Antipsychotic associated akathisia is a highly relevant clinical phenomenon. The common side effect can be stigmatizing, cause subjective distress and depression, lead to medication noncompliance and be potentially disabling for patients with psychosis.… read more here.
Keywords: depression; akathisia; atypical antipsychotics; suicidality ... See more keywords
M210. GRIN2B METHYLATION IS RELATED TO PANSS EXCITED COMPONENT (PANSS-EC) IN SCHIZOPHRENIA
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DOI: 10.1093/schbul/sbaa030.522
Abstract: Abstract Background Among the adversities found in schizophrenia, the dysfunctions in the glutamatergic system, specifically the N-methyl-D-aspartate receptor (NMDAR) are apparent. GRIN2B (coding a NMDAR subunit) has a critical role in synaptic plasticity and important… read more here.
Keywords: methylation; grin2b methylation; schizophrenia; panss ... See more keywords
S240. DETERMINANT FACTORS OF REAL-WORLD FUNCTIONING IN SCHIZOPHRENIA
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DOI: 10.1093/schbul/sby018.1027
Abstract: Abstract Background Negative, cognitive and depressive symptoms, as well as physical comorbidities, have a great impact on the real-world functioning in patients with schizophrenia (SZ) (1, 2, 3). However, not all the studies have employed… read more here.
Keywords: real world; schizophrenia; negative symptoms; world functioning ... See more keywords
Early improvement as a predictor of later response to lurasidone in schizophrenia from Japan trials: A diagnostic test
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DOI: 10.1111/pcn.13377
Abstract: A recent 6-week, double-blind, randomized, placebo-controlled trial on lurasidone for acute schizophrenia in Japan 1 demonstrated that lurasidone (LUR) 40 mg/day (LUR40) improved Positive and Negative Syndrome Scale (PANSS) 2 total score (PANSS-T) while being… read more here.
Keywords: japan trials; schizophrenia; lurasidone; panss ... See more keywords
Validation of the Arabic version of the “self-evaluation of negative symptoms” scale (SNS)
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DOI: 10.1186/s12888-020-02647-4
Abstract: Background The self-evaluation of negative symptoms scale (SNS) is a new easy-to-use self-administered questionnaire allowing clinicians to understand the clinical and genetic factors affecting the negative symptoms in patients with schizophrenia. There was a need… read more here.
Keywords: self evaluation; evaluation negative; negative symptoms; arabic version ... See more keywords
Effects of asenapine on agitation and hostility in adults with acute manic or mixed episodes associated with bipolar I disorder
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DOI: 10.2147/ndt.s149376
Abstract: Background Bipolar disorder is associated with an increased risk of aggression. However, effective management of hostility and/or agitation symptoms may prevent patients from becoming violent. This analysis investigated the efficacy of the antipsychotic asenapine on… read more here.
Keywords: manic mixed; agitation; hostility; bipolar disorder ... See more keywords