Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.016
Abstract: The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the… read more here.
Keywords: panx1; destination consequences; panx1 mutant; mdck cells ... See more keywords
Pannexin1 links lymphatic function to lipid metabolism and atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14130-4
Abstract: Extracellular ATP is a central signaling molecule in inflammatory responses. Pannexin1 (Panx1) channels release ATP in a controlled manner and have been implicated in various inflammatory pathologies, but their role in atherogenesis remains elusive. Using… read more here.
Keywords: panx1; lymphatic function; mice; function ... See more keywords
Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34234-9
Abstract: Pannexin 1 (Panx1) is a channel-forming glycoprotein important in paracrine signaling and cellular development. In this study, we discovered that mice globally lacking Panx1 (KO) have significantly greater total fat mass and reduced lean mass… read more here.
Keywords: panx1; fat accumulation; differentiation; adipose stromal ... See more keywords
Hematopoietic pannexin 1 function is critical for neuropathic pain
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42550
Abstract: Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like… read more here.
Keywords: panx1; neuropathic pain; hypersensitivity; nerve injury ... See more keywords
NEURONAL PANNEXIN-1 SHAPES INTESTINAL IMMUNE PROFILES AND FUNCTIONS
Sign Up to like & getrecommendations! Published in 2025 at "Gastroenterology"
DOI: 10.1053/j.gastro.2025.01.159
Abstract: Integration between neural and immune systems is critical for gastrointestinal functions, and disruptions of this communication contribute to inflammatory bowel disease (IBD). Pannexin-1 (Panx1) is a membrane channel expressed by enteric neurons and immune cells… read more here.
Keywords: neuronal panx1; panx1; communication; panx1 expression ... See more keywords
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112870119
Abstract: Significance Pannexin-1 (Panx1) channels contribute to neurological disorders, including stroke and epilepsy, where their function has been linked to N-methyl D-aspartate (NMDA) receptors (NMDARs). We discovered that Ca2+ entry via NMDARs recruits endoplasmic reticulum–resident STIM… read more here.
Keywords: activation; nmda receptors; panx1; ca2 entry ... See more keywords
Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab326
Abstract: AIMS Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signaling mechanisms… read more here.
Keywords: pulmonary vasoconstriction; panx1; hypoxic pulmonary; hypoxic ... See more keywords
Pannexin-1 in the CNS: emerging concepts in health and disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15004
Abstract: Pannexin-1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non-selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well-characterized with… read more here.
Keywords: panx1; cns emerging; emerging concepts; disease ... See more keywords
Pannexins in Acute Kidney Injury
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DOI: 10.1159/000501278
Abstract: Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently… read more here.
Keywords: kidney injury; panx1; pannexins acute; pathology ... See more keywords
A novel heterozygous missense variant of PANX1 causes human oocyte death and female infertility
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Ovarian Research"
DOI: 10.1186/s13048-024-01462-9
Abstract: Pannexin1 (PANX1) is a highly glycosylated membrane channel-forming protein, which has been found to implicate in multiple physiological and pathophysiological functions. Variants in the PANX1 gene have been reported to be associated with oocyte death… read more here.
Keywords: human oocyte; variant; panx1; novel heterozygous ... See more keywords
Neuronal Panx1 drives peripheral sensitization in experimental plantar inflammatory pain
Sign Up to like & getrecommendations! Published in 2024 at "Military Medical Research"
DOI: 10.1186/s40779-024-00525-8
Abstract: The channel-forming protein Pannexin1 (Panx1) has been implicated in both human studies and animal models of chronic pain, but the underlying mechanisms remain incompletely understood. Wild-type (WT, n = 24), global Panx1 KO (n = 24), neuron-specific Panx1 KO… read more here.
Keywords: pain; group; neuronal panx1; excitability ... See more keywords