Destination and consequences of Panx1 and mutant expression in polarized MDCK cells.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2019.05.016
Abstract: The channel-forming membrane glycoprotein pannexin 1 (Panx1) is best characterized as an ATP release channel. To investigate the trafficking and sorting of Panx1, we used polarized MDCK cells and non-polarized BICR-M1Rk cells to track the… read more here.
Keywords: panx1; destination consequences; panx1 mutant; mdck cells ... See more keywords
Pannexin1 links lymphatic function to lipid metabolism and atherosclerosis
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14130-4
Abstract: Extracellular ATP is a central signaling molecule in inflammatory responses. Pannexin1 (Panx1) channels release ATP in a controlled manner and have been implicated in various inflammatory pathologies, but their role in atherogenesis remains elusive. Using… read more here.
Keywords: panx1; lymphatic function; mice; function ... See more keywords
Pannexin 1 regulates adipose stromal cell differentiation and fat accumulation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-34234-9
Abstract: Pannexin 1 (Panx1) is a channel-forming glycoprotein important in paracrine signaling and cellular development. In this study, we discovered that mice globally lacking Panx1 (KO) have significantly greater total fat mass and reduced lean mass… read more here.
Keywords: panx1; fat accumulation; differentiation; adipose stromal ... See more keywords
Hematopoietic pannexin 1 function is critical for neuropathic pain
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep42550
Abstract: Neuropathic pain symptoms respond poorly to available therapeutics, with most treated patients reporting unrelieved pain and significant impairment in daily life. Here, we show that Pannexin 1 (Panx1) in hematopoietic cells is required for pain-like… read more here.
Keywords: panx1; neuropathic pain; hypersensitivity; nerve injury ... See more keywords
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112870119
Abstract: Significance Pannexin-1 (Panx1) channels contribute to neurological disorders, including stroke and epilepsy, where their function has been linked to N-methyl D-aspartate (NMDA) receptors (NMDARs). We discovered that Ca2+ entry via NMDARs recruits endoplasmic reticulum–resident STIM… read more here.
Keywords: activation; nmda receptors; panx1; ca2 entry ... See more keywords
Pannexin 1-a novel regulator of acute hypoxic pulmonary vasoconstriction.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab326
Abstract: AIMS Hypoxic pulmonary vasoconstriction (HPV) is a physiological response to alveolar hypoxia that diverts blood flow from poorly ventilated to better aerated lung areas to optimize ventilation-perfusion matching. Yet, the exact sensory and signaling mechanisms… read more here.
Keywords: pulmonary vasoconstriction; panx1; hypoxic pulmonary; hypoxic ... See more keywords
Pannexin-1 in the CNS: emerging concepts in health and disease.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15004
Abstract: Pannexin-1 (Panx1) is a large pore membrane channel with unique conduction properties ranging from non-selective ion permeability to the extracellular release of signalling molecules. The release of ATP by Panx1 has been particularly well-characterized with… read more here.
Keywords: panx1; cns emerging; emerging concepts; disease ... See more keywords
Pannexins in Acute Kidney Injury
Sign Up to like & getrecommendations! Published in 2019 at "Nephron"
DOI: 10.1159/000501278
Abstract: Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently… read more here.
Keywords: kidney injury; panx1; pannexins acute; pathology ... See more keywords
Pannexin1 channels—a potential therapeutic target in inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1020826
Abstract: An exaggerated inflammatory response is the hallmark of a plethora of disorders. ATP is a central signaling molecule that orchestrates the initiation and resolution of the inflammatory response by enhancing activation of the inflammasome, leukocyte… read more here.
Keywords: inflammation; inflammatory response; panx1; panx1 channels ... See more keywords
Role of Pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.956340
Abstract: Clostridioides difficile (C. difficile) produces toxins A (TcdA) and B (TcdB), both associated with intestinal damage and diarrhea. Pannexin-1 (Panx1) channels allows the passage of messenger molecules, such as adenosine triphosphate (ATP), which in turn… read more here.
Keywords: cell death; tcda tcdb; panx1; expression ... See more keywords
A Potential Compensatory Role of Panx3 in the VNO of a Panx1 Knock Out Mouse Model
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00135
Abstract: Pannexins (Panx) are integral membrane proteins, with Panx1 being the best-characterized member of the protein family. Panx1 is implicated in sensory processing, and knockout (KO) animal models have become the primary tool to investigate the… read more here.
Keywords: loss panx1; panx1; expression; role ... See more keywords