SARS‐CoV‐2 Papain‐Like Protease: Structure, Function and Inhibition
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DOI: 10.1002/cbic.202200327
Abstract: Emerging variants of SARS‐CoV‐2 and potential novel epidemic coronaviruses underline the importance of investigating various viral proteins as potential drug targets. The papain‐like protease of coronaviruses has been less explored than other viral proteins; however,… read more here.
Keywords: like protease; papain like; structure function; sars cov ... See more keywords
Mass spectrometric assays reveal discrepancies in inhibition profiles for the SARS-CoV-2 papain-like protease.
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DOI: 10.1002/cmdc.202200016
Abstract: The two SARS-CoV-2 proteases, i.e. the main protease (M pro ) and the papain-like protease (PL pro ), which hydrolyze the viral polypeptide chain giving functional non-structural proteins, are essential for viral replication and are… read more here.
Keywords: pro inhibitors; sars cov; mass; papain like ... See more keywords
In Silico Analysis of Inhibiting Papain-like Protease from SARS-CoV-2 by Using Plant-Derived Peptides
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DOI: 10.1007/s10989-021-10331-8
Abstract: SARS-CoV-2 is a corona virus that has been the cause for one of the deadliest pandemics of history, started since 2019. Suppressing the activity of the critical enzymes in the SARS-CoV-2 could potentially inhibit a… read more here.
Keywords: papain like; plant derived; like protease; sars cov ... See more keywords
Exploring naphthyl derivatives as SARS-CoV papain-like protease (PLpro) inhibitors and its implications in COVID-19 drug discovery
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Diversity"
DOI: 10.1007/s11030-021-10198-3
Abstract: Abstract Novel coronavirus disease 2019 (COVID-19) emerges as a serious threat to public health globally. The rapid spreading of COVID-19, caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2), proclaimed the multitude of applied… read more here.
Keywords: naphthyl derivatives; like protease; papain like; sars cov ... See more keywords
Porcine epidemic diarrhea virus papain-like protease 2 can be noncompetitively inhibited by 6-thioguanine
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DOI: 10.1016/j.antiviral.2018.08.011
Abstract: Abstract Porcine epidemic diarrhea virus (PEDV) is a coronavirus (CoV) discovered in the 1970s that infects the intestinal tract of pigs, resulting in diarrhea and vomiting. It can cause extreme dehydration and death in neonatal… read more here.
Keywords: porcine epidemic; epidemic diarrhea; like protease; papain like ... See more keywords
Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2
Sign Up to like & getrecommendations! Published in 2021 at "Cell Chemical Biology"
DOI: 10.1016/j.chembiol.2021.04.020
Abstract: The COVID-19 pandemic has been disastrous to society and effective drugs are urgent needed. The papain-like protease domain (PLpro) of SARS-CoV-2 (SCoV2) is indispensable for viral replication and represents a putative target for pharmacological intervention.… read more here.
Keywords: development potent; potent selective; like protease; papain like ... See more keywords
Targeting multiple conformations of SARS-CoV2 Papain-Like Protease for drug repositioning: An in-silico study
Sign Up to like & getrecommendations! Published in 2021 at "Computers in Biology and Medicine"
DOI: 10.1016/j.compbiomed.2021.104295
Abstract: Papain-Like Protease (PLpro) is a key protein for SARS-CoV-2 viral replication which is the cause of the emerging COVID-19 pandemic. Targeting PLpro can suppress viral replication and provide treatment options for COVID-19. Due to the… read more here.
Keywords: drug repositioning; targeting multiple; multiple conformations; like protease ... See more keywords
Structure-Based Identification of Naphthoquinones and Derivatives as Novel Inhibitors of Main Protease Mpro and Papain-like Protease PLpro of SARS-CoV-2
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DOI: 10.1021/acs.jcim.2c00693
Abstract: The worldwide COVID-19 pandemic caused by the coronavirus SARS-CoV-2 urgently demands novel direct antiviral treatments. The main protease (Mpro) and papain-like protease (PLpro) are attractive drug targets among coronaviruses due to their essential role in… read more here.
Keywords: protease; main protease; sars cov; papain like ... See more keywords
Large-Scale Virtual Screening for the Discovery of SARS-CoV-2 Papain-like Protease (PLpro) Non-covalent Inhibitors
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DOI: 10.1021/acs.jcim.2c01641
Abstract: The rapid global spread of the SARS-CoV-2 virus facilitated the development of novel direct-acting antiviral agents (DAAs). The papain-like protease (PLpro) has been proposed as one of the major SARS-CoV-2 targets for DAAs due to… read more here.
Keywords: protease plpro; plpro; like protease; papain like ... See more keywords
Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (Mpro) and Papain-like Protease (PLpro)
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.3c00168
Abstract: The SARS-CoV-2 pandemic has prompted global efforts to develop therapeutics. The main protease of SARS-CoV-2 (Mpro) and the papain-like protease (PLpro) are essential for viral replication and are key targets for therapeutic development. In this… read more here.
Keywords: inhibition; protease; main protease; papain like ... See more keywords
Design and Evaluation of a Novel Peptide–Drug Conjugate Covalently Targeting SARS-CoV-2 Papain-like Protease
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c02022
Abstract: Coronavirus disease 2019 (COVID-19) pandemic, a global health threat, was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 papain-like cysteine protease (PLpro) was recognized as a promising drug target because of multiple… read more here.
Keywords: sars cov; drug; cov papain; novel peptide ... See more keywords