Papaverine, a promising therapeutic agent for the treatment of COVID‐19 patients with underlying cardiovascular diseases (CVDs)
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DOI: 10.1002/ddr.21961
Abstract: The causative agent of coronavirus disease‐2019 (COVID‐19), severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), enters the host cells via an angiotensin‐converting enzyme 2 (ACE2)‐mediated endocytosis‐dependent manner. Because ACE2 is highly expressed in the heart, SARS‐CoV‐2… read more here.
Keywords: patients underlying; covid; treatment covid; treatment ... See more keywords
Enzyme-catalyzed regio-selective demethylation of papaverine by CYP105D1
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology Letters"
DOI: 10.1007/s10529-018-2626-0
Abstract: ObjectivesTo investigate the regio-selective demethylation of papaverine by CYP105D1 and develop a whole-cell biocatalytic system for the preparative synthesis of 6-O-demethyl-papaverine.ResultsCYP105D1 from Streptomyces griseus ATCC 13273 was used for the regioselective demethylation of papaverine at… read more here.
Keywords: papaverine; cyp105d1; selective demethylation; cell ... See more keywords
Periarterial papaverine to treat renal artery vasospasm during robot-assisted laparoscopic partial nephrectomy
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Robotic Surgery"
DOI: 10.1007/s11701-017-0710-4
Abstract: Renal artery vasospasm can be a troublesome complication during robot-assisted laparoscopic partial nephrectomy. Urologists performing this procedure, especially if utilizing selective arterial vascular microdissection, should be aware of using papaverine for both prevention and treatment… read more here.
Keywords: artery vasospasm; papaverine; renal artery; robot assisted ... See more keywords
The Efficacy of Hydrodilatation for the Prevention of Vasospasm following Microsurgical Anastomosis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of reconstructive microsurgery"
DOI: 10.1055/s-0041-1735834
Abstract: INTRODUCTION Vasospasm is a major problem following microsurgical reconstruction which can result in the partial or complete loss of the flap tissue. The aim of this study was to investigate the efficiency of hydrodilatation for… read more here.
Keywords: microscopy; hydrodilatation; papaverine; group ... See more keywords
Biosynthesis of tetrahydropapaverine and semisynthesis of papaverine in yeast
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205848119
Abstract: Significance We report the de novo microbial biosynthesis of (S)-tetrahydropapaverine (THP) and the semisynthesis of papaverine using microbially biosynthesized THP. We used protein engineering to develop variants of two enzymes with improved nonnative activity on… read more here.
Keywords: papaverine; semisynthesis papaverine; biosynthesis; biosynthesis tetrahydropapaverine ... See more keywords
Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses
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DOI: 10.1128/jvi.01888-19
Abstract: Influenza viruses are important human pathogens that are the causative agents of epidemics and pandemics. Despite the availability of an annual vaccine, a large number of cases occur every year globally. Here, we report that… read more here.
Keywords: well paramyxoviruses; influenza viruses; influenza; papaverine ... See more keywords
Anticancer Non-narcotic Opium Alkaloid Papaverine Suppresses Human Glioblastoma Cell Growth
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DOI: 10.21873/anticanres.13889
Abstract: Background: Glioblastoma (GBM) is the most aggressive type of primary malignant brain tumour. The interaction between high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is important for tumour cell growth. Previously,… read more here.
Keywords: glioblastoma; t98g cells; papaverine; cell growth ... See more keywords
THE RAPID AND GREEN HAIR ANALYSIS METHOD DEVELOPMENT USING FTIR FOR PAPAVERINE HCL DETERMINATION
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Applied Pharmaceutics"
DOI: 10.22159/ijap.2019v11i2.31225
Abstract: Objective: This study was aimed to develop a rapid analysis using FTIR (Fourier Transform Infra-Red) for papaverine hydrochloride (HCl) determination in the hair sample, supported by a mathematically manipulation; which never been reported before in… read more here.
Keywords: using ftir; hair; papaverine; method ... See more keywords
Papaverinol-N-Oxide: A Microbial Biotransformation Product of Papaverine with Potential Antidiabetic and Antiobesity Activity Unveiled with In Silico Screening
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041583
Abstract: Bioconversion of biosynthetic heterocyclic compounds has been utilized to produce new semisynthetic pharmaceuticals and study the metabolites of bioactive drugs used systemically. In this investigation, the biotransformation of natural heterocyclic alkaloid papaverine via filamentous fungi… read more here.
Keywords: glucosidase; biotransformation; papaverinol oxide; antidiabetic antiobesity ... See more keywords
Papaverine: A Miraculous Alkaloid from Opium and Its Multimedicinal Application
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28073149
Abstract: The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been found in the unripe seed capsules of Papaver somniferum L. Although it… read more here.
Keywords: miraculous alkaloid; opium multimedicinal; papaverine miraculous; alkaloid opium ... See more keywords