Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita.
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DOI: 10.1182/bloodadvances.2020001848
Abstract: Dyskeratosis congenita (DC) is a pediatric bone marrow failure syndrome caused by germline mutations in telomere biology genes. Mutations in DKC1 (the most commonly mutated gene in DC), the 3' region of TERC, and poly(A)-specific… read more here.
Keywords: chemical inhibition; telomerase function; inhibition papd5; dyskeratosis congenita ... See more keywords