Insights into the substrate binding mechanism of SULT1A1 through molecular dynamics with excited normal modes simulations
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DOI: 10.1038/s41598-021-92480-w
Abstract: Sulfotransferases (SULTs) are phase II drug-metabolizing enzymes catalyzing the sulfoconjugation from the co-factor 3′-phosphoadenosine 5′-phosphosulfate (PAPS) to a substrate. It has been previously suggested that a considerable shift of SULT structure caused by PAPS binding… read more here.
Keywords: insights substrate; paps bound; molecular dynamics; excited normal ... See more keywords