PAQR3 augments amino acid deprivation-induced autophagy by inhibiting mTORC1 signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.02.017
Abstract: Amino acids are the key activators of the mTOR complex 1 (mTORC1, mainly composed of mTOR, Raptor and mLST8) required for cell growth and proliferation. On the other hand, deprivation of amino acids induces autophagy… read more here.
Keywords: acid deprivation; paqr3; amino acid; mtorc1 signaling ... See more keywords
Silencing of PAQR3 suppresses extracellular matrix accumulation in high glucose‐stimulated human glomerular mesangial cells via PI3K/AKT signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.05.032
Abstract: ABSTRACT Progestin and AdipoQ Receptor 3 (PAQR3), a member of the PAQR family, was involved in multiple biological processes, including tumorigenesis, cholesterol homeostasis, autophagy, obesity, insulin sensitivity and energy metabolism. However, the role of PAQR3… read more here.
Keywords: accumulation; extracellular matrix; pi3k akt; human glomerular ... See more keywords
Suppressor PAQR3 associated with the clinical significance and prognosis in esophageal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Oncology Letters"
DOI: 10.3892/ol.2018.8004
Abstract: Progestin and adipoQ receptor family member 3 (PAQR3) is a novel tumor suppressor; however, its function in esophageal cancer is not well understood. The present study explored the association between PAQR3, and the survival and… read more here.
Keywords: paqr3 expression; cell carcinoma; squamous cell; expression ... See more keywords