Plasmin reduces fibronectin deposition by mesangial cells in a protease-activated receptor-1 independent manner
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DOI: 10.1016/j.bbrep.2017.03.009
Abstract: Background Protease-activated receptor-1 (PAR-1) potentiates diabetic nephropathy (DN) as evident from reduced kidney injury in diabetic PAR-1 deficient mice. Although thrombin is the prototypical PAR-1 agonist, anticoagulant treatment does not limit DN in experimental animal… read more here.
Keywords: fibronectin deposition; protease; par agonist; par ... See more keywords