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Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7427
Abstract: Most antiangiogenic inhibitors targeting endothelium‐dependent vessels cannot inhibit tumor growth but promote tumor invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct endothelium‐dependent vessels. Inhibiting VM…
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Keywords:
hepatocellular carcinoma;
myricetin;
vasculogenic mimicry;
invasion ... See more keywords
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Published in 2017 at "Inflammatory Bowel Diseases"
DOI: 10.1097/mib.0000000000001045
Abstract: Background: Proteolytic cleavage of protease-activated receptor 1 (PAR1) can result in potent downstream regulatory effects on inflammation. Although PAR1 is expressed throughout the gastrointestinal tract and activating proteases are increased in inflammatory bowel disease, the…
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Keywords:
par1;
disease;
colitis;
protease activated ... See more keywords
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Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15115
Abstract: Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells drives an immunosuppressive gene signature.…
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Keywords:
thrombin par1;
par1 signaling;
pdac tumor;
par1 ... See more keywords
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Published in 2017 at "Botany"
DOI: 10.1139/cjb-2016-0321
Abstract: The Arabidopsis paraquat resistant1 (PAR1) was classified as L-type amino acid transporter 4 (LAT4) based on a phylogenetic analysis of selected genes from Saccharomyces cerevisiae, Arabidopsis thaliana (L.) Heynh, and Homo sapiens that clustered LAT4…
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Keywords:
arabidopsis paraquat;
amino acid;
paraquat resistant1;
par1 ... See more keywords
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2
Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734190
Abstract: Airway hyperreactivity (AHR) is a hallmark of allergic asthma, and the major cause of exacerbations. Although acute bronchospasm can be mitigated by bronchodilators and corticosteroids, no therapeutics effectively target AHR. Recent studies have shown that…
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Keywords:
airway hyperreactivity;
hdm;
physiology;
mice ... See more keywords
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Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.314560
Abstract: Supplemental Digital Content is available in the text. Objective: Remodeling of the extracellular matrix plays a vital role in cardiovascular diseases. Using a mouse model of postnatal ascending aortic aneurysms (termed Fbln4SMKO), we have reported…
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Keywords:
aneurysm;
par1 egr1;
role;
mice ... See more keywords
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Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tmp27
Abstract: 3K3A-APC is a recombinant variant of activated protein C (APC) with > 90% reduced anticoagulant activity but preserved cell signaling activity. Benefical effects are mediated by its antiapoptotic direct neuronal protective and vasculoprotective effects including…
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Keywords:
3k3a apc;
white matter;
stroke;
par1 ... See more keywords
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Published in 2021 at "Blood"
DOI: 10.1182/blood.2020008417
Abstract: Recombinant FVIIa (rFVIIa) is used as a hemostatic agent to treat bleeding disorders in hemophilia patients with inhibitors and other groups of patients. Our recent studies showed that FVIIa binds endothelial cell protein C receptor…
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Keywords:
extracellular vesicles;
fviia;
par1;
epcr ... See more keywords
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Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160926120904
Abstract: BACKGROUND Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression. In order to investigate on potential use of…
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Keywords:
par1;
arylpiperazine derivatives;
antiproliferative agents;
protease activated ... See more keywords
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2
Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1082712
Abstract: Riemerella anatipestifer mainly infects domestic ducks, geese, turkeys, and other birds, and causes considerable economic losses to the global duck industry. Previous studies have shown that concentrated cell-free culture filtrates of R. anatipestifer induce highly…
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Keywords:
serotype;
riemerella anatipestifer;
par1;
yb2 ... See more keywords
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Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01283
Abstract: The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders. Previous studies reported connections between AngII and thrombin…
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Keywords:
type receptor;
par1;
at1r;
interaction ... See more keywords