Myricetin reverses epithelial–endothelial transition and inhibits vasculogenic mimicry and angiogenesis of hepatocellular carcinoma by directly targeting PAR1
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7427
Abstract: Most antiangiogenic inhibitors targeting endothelium‐dependent vessels cannot inhibit tumor growth but promote tumor invasion and metastasis in some patients. Vasculogenic mimicry (VM) employs mechanisms that differ from those used to construct endothelium‐dependent vessels. Inhibiting VM… read more here.
Keywords: hepatocellular carcinoma; myricetin; vasculogenic mimicry; invasion ... See more keywords
USP34 regulates endothelial PAR1 mRNA transcript expression and cellular signaling
Sign Up to like & getrecommendations! Published in 2024 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e24-07-0294
Abstract: Signaling by G protein-coupled receptors (GPCRs) is regulated by temporally distinct processes including receptor desensitization, internalization, and lysosomal sorting, and are tightly controlled by posttranslational modifications. While the role of phosphorylation in regulating GPCR signaling… read more here.
Keywords: ubiquitination; mrna transcript; transcript expression; par1 ... See more keywords
Protease-activated Receptor 1 Plays a Proinflammatory Role in Colitis by Promoting Th17-related Immunity
Sign Up to like & getrecommendations! Published in 2017 at "Inflammatory Bowel Diseases"
DOI: 10.1097/mib.0000000000001045
Abstract: Background: Proteolytic cleavage of protease-activated receptor 1 (PAR1) can result in potent downstream regulatory effects on inflammation. Although PAR1 is expressed throughout the gastrointestinal tract and activating proteases are increased in inflammatory bowel disease, the… read more here.
Keywords: par1; disease; colitis; protease activated ... See more keywords
Thrombin‐PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15115
Abstract: Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells drives an immunosuppressive gene signature.… read more here.
Keywords: thrombin par1; par1 signaling; pdac tumor; par1 ... See more keywords
The Arabidopsis paraquat resistant1 mutant accumulates leucine upon dark treatment
Sign Up to like & getrecommendations! Published in 2017 at "Botany"
DOI: 10.1139/cjb-2016-0321
Abstract: The Arabidopsis paraquat resistant1 (PAR1) was classified as L-type amino acid transporter 4 (LAT4) based on a phylogenetic analysis of selected genes from Saccharomyces cerevisiae, Arabidopsis thaliana (L.) Heynh, and Homo sapiens that clustered LAT4… read more here.
Keywords: arabidopsis paraquat; amino acid; paraquat resistant1; par1 ... See more keywords
Vagal C-fibers mediate HDM induced airway hyperreactivity via PAR1 receptors
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734190
Abstract: Airway hyperreactivity (AHR) is a hallmark of allergic asthma, and the major cause of exacerbations. Although acute bronchospasm can be mitigated by bronchodilators and corticosteroids, no therapeutics effectively target AHR. Recent studies have shown that… read more here.
Keywords: airway hyperreactivity; hdm; physiology; mice ... See more keywords
Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.314560
Abstract: Supplemental Digital Content is available in the text. Objective: Remodeling of the extracellular matrix plays a vital role in cardiovascular diseases. Using a mouse model of postnatal ascending aortic aneurysms (termed Fbln4SMKO), we have reported… read more here.
Keywords: aneurysm; par1 egr1; role; mice ... See more keywords
Thrombomodulin Switches Signaling and Protease-Activated Receptor 1 Cleavage Specificity of Thrombin
Sign Up to like & getrecommendations! Published in 2024 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.123.320185
Abstract: BACKGROUND: Cleavage of the extracellular domain of PAR1 (protease-activated receptor 1) by thrombin at Arg41 and by APC (activated protein C) at Arg46 initiates paradoxical cytopathic and cytoprotective signaling in endothelial cells. In the latter… read more here.
Keywords: receptor; thrombomodulin; par1; specificity ... See more keywords
Abstract TMP27: Par1 Mediates Protective Effect of 3K3K-APC After White Matter Stroke in Mice
Sign Up to like & getrecommendations! Published in 2020 at "Stroke"
DOI: 10.1161/str.51.suppl_1.tmp27
Abstract: 3K3A-APC is a recombinant variant of activated protein C (APC) with > 90% reduced anticoagulant activity but preserved cell signaling activity. Benefical effects are mediated by its antiapoptotic direct neuronal protective and vasculoprotective effects including… read more here.
Keywords: 3k3a apc; white matter; stroke; par1 ... See more keywords
Factor VIIa induces extracellular vesicles from the endothelium: A potential mechanism for its hemostatic effect.
Sign Up to like & getrecommendations! Published in 2021 at "Blood"
DOI: 10.1182/blood.2020008417
Abstract: Recombinant FVIIa (rFVIIa) is used as a hemostatic agent to treat bleeding disorders in hemophilia patients with inhibitors and other groups of patients. Our recent studies showed that FVIIa binds endothelial cell protein C receptor… read more here.
Keywords: extracellular vesicles; fviia; par1; epcr ... See more keywords
Synthesis of Arylpiperazine Derivatives as Protease Activated Receptor 1 Antagonists and Their Evaluation as Antiproliferative Agents.
Sign Up to like & getrecommendations! Published in 2017 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520616666160926120904
Abstract: BACKGROUND Protease activated receptor-1 (PAR1) is a G-coupled receptor activated by α-thrombin and other proteases. Several reports have demonstrated the PAR1 involvement in tumorigenesis and tumor progression. In order to investigate on potential use of… read more here.
Keywords: par1; arylpiperazine derivatives; antiproliferative agents; protease activated ... See more keywords