Baicalein promotes KDM4E to induce BICD1 and inhibit triple‐negative breast cancer progression by blocking PAR1 signaling
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DOI: 10.1002/mc.23724
Abstract: Baicalein has been implicated in the chemotherapy overcoming triple‐negative breast cancer (TNBC). However, many unanswered questions remain regarding its role in treating TNBC. Here, we sought to demonstrate the molecular pathway mediated by baicalein in… read more here.
Keywords: baicalein; bicd1; progression; par1 signaling ... See more keywords
Thrombin‐PAR1 signaling in pancreatic cancer promotes an immunosuppressive microenvironment
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DOI: 10.1111/jth.15115
Abstract: Essentials Elimination of PDAC tumor cell PAR1 increased cytotoxic T cells and reduced tumor macrophages. PAR1KO PDAC cells are preferentially eliminated from growing tumors. Thrombin‐PAR1 signaling in PDAC tumor cells drives an immunosuppressive gene signature.… read more here.
Keywords: thrombin par1; par1 signaling; pdac tumor; par1 ... See more keywords