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   Articles with "par2" as a keyword



Endothelial PAR2 activation evokes resistance artery relaxation

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recommendations! Published in 2023 at "Journal of Cellular Physiology"

DOI: 10.1002/jcp.30973

Abstract: Protease‐activated receptor‐1 & ‐2 (PAR1 and PAR2) are expressed widely in cardiovascular tissues including endothelial and smooth muscle cells. PAR1 and PAR2 may regulate blood pressure via changes in vascular contraction or relaxation mediated by… read more here.

Keywords: par2 activation; endothelial cells; relaxation; par2 ... See more keywords

Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.

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recommendations! Published in 2019 at "Archives of biochemistry and biophysics"

DOI: 10.1016/j.abb.2019.01.019

Abstract: Human airway trypsin-like protease (HAT) localizes at human bronchial epithelial cells (HBECs). HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 μM leupeptin, a… read more here.

Keywords: par2; trypsin like; epithelial cells; protease ... See more keywords

Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer.

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recommendations! Published in 2021 at "Cancer letters"

DOI: 10.1016/j.canlet.2021.05.040

Abstract: The Bcl-2 homolog Bcl-xL is emerging as a key factor in tumorigenesis due to its prominent pro-survival and cell death-independent functions. However, the regulation of Bcl-xL by microenvironment and its implication in cancer therapy of… read more here.

Keywords: par2; egfr targeted; protease activated; activated receptor ... See more keywords

Protease activated receptor 2 signaling promotes self-renewal and metastasis in colorectal cancer through β-catenin and periostin.

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recommendations! Published in 2021 at "Cancer letters"

DOI: 10.1016/j.canlet.2021.08.032

Abstract: The maintenance and expansion of cancer stem-like cells (CSCs) is necessary for metastasis. Although protease-activated receptor 2 (PAR2) is strongly associated with colorectal cancer (CRC) progression, it is unclear how it regulates distal metastasis, and… read more here.

Keywords: par2; catenin; protease activated; activated receptor ... See more keywords

PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease

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recommendations! Published in 2019 at "Molecular Metabolism"

DOI: 10.1016/j.molmet.2019.08.019

Abstract: Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role… read more here.

Keywords: par2; homeostasis; fatty liver; cholesterol ... See more keywords

N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-ҡB axis

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recommendations! Published in 2020 at "Neurochemistry International"

DOI: 10.1016/j.neuint.2019.104602

Abstract: BACKGROUND AND AIM Oxidative stress (OS) is accused in pathogenesis of many diseases, including liver cirrhosis by many mechanisms. One of them is the disturbance of long non coding maternally expressed 3 (MEG3)/protease activated receptor… read more here.

Keywords: par2; meg3 par2; meg3; liver cirrhosis ... See more keywords

Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2112059119

Abstract: Significance Colonic epithelial cells protect against inflammation by forming a barrier against ingress of microbes, digestive enzymes, and metabolic waste from the lumen. Protease-activated receptor-2 (PAR2) mediates the proinflammatory and pronociceptive actions of proteases. We… read more here.

Keywords: inflammation; par2 mugfp; endocytosis; mice ... See more keywords

Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2

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recommendations! Published in 2024 at "Gut Microbes"

DOI: 10.1080/19490976.2024.2387857

Abstract: ABSTRACT Imbalances in proteolytic activity have been linked to the development of inflammatory bowel diseases (IBD) and experimental colitis. Proteases in the intestine play important roles in maintaining homeostasis, but exposure of mucosal tissues to… read more here.

Keywords: par2; expansion; external domain; domain par2 ... See more keywords

P124 Tissue Factor and Protease-Activated Receptor 2 associated genes are upregulated in patients with Inflammatory Bowel Disease

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recommendations! Published in 2024 at "Journal of Crohn's and Colitis"

DOI: 10.1093/ecco-jcc/jjad212.0254

Abstract: Tissue Factor (TF) is well known for its role in coagulation, but it is also a key mediator of inflammatory cellular signaling relating to myeloid cell migration and kinase activation. TF is upregulated during inflammation… read more here.

Keywords: activated receptor; par2; inflamed tissue; tissue ... See more keywords

Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.

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recommendations! Published in 2019 at "European heart journal"

DOI: 10.1093/eurheartj/ehz117

Abstract: AIMS Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and… read more here.

Keywords: par2; fibrosis; cardiac fibrosis; protease activated ... See more keywords

Deficiency of protease-activated receptor (PAR) 1 and PAR2 exacerbates collagen-induced arthritis in mice via differing mechanisms.

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recommendations! Published in 2020 at "Rheumatology"

DOI: 10.1093/rheumatology/keaa701

Abstract: OBJECTIVES Protease-activated receptor (PAR) 1 and PAR2 have been implicated in RA, however their exact role is unclear. Here, we detailed the mechanistic impact of these receptors on the onset and development of inflammatory arthritis… read more here.

Keywords: par2; induced arthritis; receptor par; par par2 ... See more keywords