Endothelial PAR2 activation evokes resistance artery relaxation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30973
Abstract: Protease‐activated receptor‐1 & ‐2 (PAR1 and PAR2) are expressed widely in cardiovascular tissues including endothelial and smooth muscle cells. PAR1 and PAR2 may regulate blood pressure via changes in vascular contraction or relaxation mediated by… read more here.
Keywords: par2 activation; endothelial cells; relaxation; par2 ... See more keywords
Human airway trypsin-like protease enhances interleukin-8 synthesis in bronchial epithelial cells by activating protease-activated receptor 2.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.01.019
Abstract: Human airway trypsin-like protease (HAT) localizes at human bronchial epithelial cells (HBECs). HAT enhanced release of interleukin-8 (IL-8) from HBECs at 10-100 mU/mL and the enhanced release was almost completely abolished by 50 μM leupeptin, a… read more here.
Keywords: par2; trypsin like; epithelial cells; protease ... See more keywords
Protease-activated receptor 2 stabilizes Bcl-xL and regulates EGFR-targeted therapy response in colorectal cancer.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.05.040
Abstract: The Bcl-2 homolog Bcl-xL is emerging as a key factor in tumorigenesis due to its prominent pro-survival and cell death-independent functions. However, the regulation of Bcl-xL by microenvironment and its implication in cancer therapy of… read more here.
Keywords: par2; egfr targeted; protease activated; activated receptor ... See more keywords
Protease activated receptor 2 signaling promotes self-renewal and metastasis in colorectal cancer through β-catenin and periostin.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.08.032
Abstract: The maintenance and expansion of cancer stem-like cells (CSCs) is necessary for metastasis. Although protease-activated receptor 2 (PAR2) is strongly associated with colorectal cancer (CRC) progression, it is unclear how it regulates distal metastasis, and… read more here.
Keywords: par2; catenin; protease activated; activated receptor ... See more keywords
PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2019.08.019
Abstract: Objective Increases in hepatic and plasma cholesterol occur in patients with nonalcoholic fatty liver disease (NAFLD), although the reason for this is not well understood. We investigated whether Protease-Activated Receptor 2 (PAR2) plays a role… read more here.
Keywords: par2; homeostasis; fatty liver; cholesterol ... See more keywords
N-acetylcysteine (NAC) alleviates the peripheral neuropathy associated with liver cirrhosis via modulation of neural MEG3/PAR2/ NF-ҡB axis
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2019.104602
Abstract: BACKGROUND AND AIM Oxidative stress (OS) is accused in pathogenesis of many diseases, including liver cirrhosis by many mechanisms. One of them is the disturbance of long non coding maternally expressed 3 (MEG3)/protease activated receptor… read more here.
Keywords: par2; meg3 par2; meg3; liver cirrhosis ... See more keywords
Mice expressing fluorescent PAR2 reveal that endocytosis mediates colonic inflammation and pain
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112059119
Abstract: Significance Colonic epithelial cells protect against inflammation by forming a barrier against ingress of microbes, digestive enzymes, and metabolic waste from the lumen. Protease-activated receptor-2 (PAR2) mediates the proinflammatory and pronociceptive actions of proteases. We… read more here.
Keywords: inflammation; par2 mugfp; endocytosis; mice ... See more keywords
Protease-activated receptor 2 deficiency mediates cardiac fibrosis and diastolic dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "European heart journal"
DOI: 10.1093/eurheartj/ehz117
Abstract: AIMS Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging share a complex pathophysiology, including extracellular matrix remodelling (EMR). Protease-activated receptor 2 (PAR2) deficiency is associated with EMR. The roles of PAR1 and… read more here.
Keywords: par2; fibrosis; cardiac fibrosis; protease activated ... See more keywords
Deficiency of protease-activated receptor (PAR) 1 and PAR2 exacerbates collagen-induced arthritis in mice via differing mechanisms.
Sign Up to like & getrecommendations! Published in 2020 at "Rheumatology"
DOI: 10.1093/rheumatology/keaa701
Abstract: OBJECTIVES Protease-activated receptor (PAR) 1 and PAR2 have been implicated in RA, however their exact role is unclear. Here, we detailed the mechanistic impact of these receptors on the onset and development of inflammatory arthritis… read more here.
Keywords: par2; induced arthritis; receptor par; par par2 ... See more keywords
Low-density lipoprotein receptor-related protein 6 is a novel coreceptor of protease-activated receptor-2 in the dynamics of cancer-associated β-catenin stabilization
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.16246
Abstract: Protease-activated receptor-2 (PAR2) plays a central role in cancer; however, the molecular machinery of PAR2-instigated tumors remains to be elucidated. We show that PAR2 is a potent inducer of β-catenin stabilization, a core process in… read more here.
Keywords: par2; biology; cancer; receptor ... See more keywords
Candida albicans Sap6 Initiates Oral Mucosal Inflammation via the Protease Activated Receptor PAR2
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.912748
Abstract: Candida albicans Sap6, a secreted aspartyl protease (Sap), contributes to fungal virulence in oral candidiasis. Beside its protease activity, Sap6 contains RGD (RGDRGD) motif required for its binding to host integrins. Sap6 activates immune cells… read more here.
Keywords: albicans sap6; rsap6; protease activated; par2 ... See more keywords