Shared and independent functions of aPKCĪ» and Par3 in skin tumorigenesis
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DOI: 10.1038/s41388-018-0313-1
Abstract: The polarity proteins Par3 and aPKC are key regulators of processes altered in cancer. Par3/aPKC are thought to dynamically interact with Par6 but increasing evidence suggests that aPKC and Par3 also exert complex-independent functions. Whereas… read more here.
Keywords: par3; par3 apkc; tumorigenesis; independent functions ... See more keywords
Structural basis for the interaction between the cell polarity proteins Par3 and Par6
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DOI: 10.1126/scisignal.aam9899
Abstract: The association between the polarity proteins Par6 and Par3 requires a motif in Par6 that binds to two of the PDZ domains in Par3. Building a polarity scaffold Cell types often exhibit asymmetric distributions of… read more here.
Keywords: protein; par3; polarity; pdz ... See more keywords
Dual Function of Par3 in Tumorigenesis
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DOI: 10.3389/fonc.2022.915957
Abstract: Cell maintenance and the establishment of cell polarity involve complicated interactions among multiple protein complexes as well as the regulation of different signaling pathways. As an important cell polarity protein, Par3 is evolutionarily conserved and… read more here.
Keywords: cell; par3; tumorigenesis; function par3 ... See more keywords