Structural basis for the interaction between the cell polarity proteins Par3 and Par6
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DOI: 10.1126/scisignal.aam9899
Abstract: The association between the polarity proteins Par6 and Par3 requires a motif in Par6 that binds to two of the PDZ domains in Par3. Building a polarity scaffold Cell types often exhibit asymmetric distributions of… read more here.
Keywords: protein; par3; polarity; pdz ... See more keywords
Suppression of CIP4/Par6 attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells
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DOI: 10.3892/ijmm.2017.3100
Abstract: Transforming growth factor-β (TGF-β) induces epithelial-mesenchymal transition (EMT) primarily via a Smad-dependent mechanism. However, there are few studies available on TGF-β-induced EMT through the activation of non-canonical pathways. In this study, the Cdc42-interacting protein-4 (CIP4)/partitioning-defective… read more here.
Keywords: nrk 52e; cip4; tgf; expression ... See more keywords