A theoretical investigation on decarboxylation mechanism of antibiotic para-aminosalicylic acid to highly toxic form meta-aminophenol
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DOI: 10.1007/s11224-020-01676-9
Abstract: The antibiotic para-aminosalicylic acid (PAS) is decomposed into its decarboxylated product, meta-aminophenol, with a series of toxicity symptoms including hemolytic anemia. The present trial investigates the decarboxylation mechanism of PAS, along with an in-detail assessment… read more here.
Keywords: mechanism; antibiotic para; decarboxylation; aminosalicylic acid ... See more keywords
Pharmacokinetics and Dose Optimization Strategies of Para-Aminosalicylic Acid in Children with Rifampicin-Resistant Tuberculosis
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DOI: 10.1128/aac.02264-21
Abstract: Treatment options for children with Rifampicin-resistant tuberculosis (RR-TB) remain limited, and para-aminosalicylic acid (PAS) is still a relevant component of treatment regimens. Prevention of resistance to companion drugs by PAS is dose related, and at… read more here.
Keywords: pas; rifampicin resistant; para aminosalicylic; children rifampicin ... See more keywords