Ligand-Promoted Nickel-Catalyzed para-Selective Carboxylation of Anisoles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00417
Abstract: It has always been a challenge in free radical chemistry to control site selectivity during the reaction of free radicals with aromatic rings. Herein, we report the site-selective carboxylation of anisoles through the direct reaction… read more here.
Keywords: selective carboxylation; carboxylation; ligand promoted; para selective ... See more keywords
para-Selective Alkylation of Sulfonylarenes by Cooperative Nickel/Aluminum Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03741
Abstract: A method for the para-selective alkylation of a variety of arenesulfonamides and aromatic sulfones with 1-alkenes by cooperative nickel/aluminum catalysis has been developed. Taking advantage of the sulfornyl functionality serving as a removable ortho-directing group,… read more here.
Keywords: nickel aluminum; selective alkylation; para selective; aluminum catalysis ... See more keywords
Scandium-Catalyzed para-Selective Alkylation of Aromatic Amines with Alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03451
Abstract: An efficient para-alkylation of primary and secondary anilines with a variety of sterically encumbered alkenes using a simple β-diketiminato scandium catalyst is reported. This protocol features 100% atom economy, excellent chemo- and regioselectivity, broad substrate… read more here.
Keywords: scandium catalyzed; selective alkylation; para selective; alkylation aromatic ... See more keywords
Highly Efficient and para-Selective C-H Functionalization of Polystyrene Providing a Versatile Platform for Diverse Applications.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00541
Abstract: Postpolymerization modification of polystyrene (PS) can afford numerous value-added materials with different functions and applications, but it has been hampered by the lack of efficient methods. We report herein a highly efficient and para-selective conversion… read more here.
Keywords: providing versatile; efficient para; versatile platform; highly efficient ... See more keywords
Amide-Ligand-Controlled Highly para-Selective Arylation of Monosubstituted Simple Arenes with Arylboronic Acids.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.6b12907
Abstract: Pd-catalyzed highly para-selective arylations of monosubstituted simple arenes with arylboronic acids to widely existed biaryls have been developed. Inspired by requisite amide-directing groups in reported selective oxidative couplings, amide ligands, especially DMF, are designed and… read more here.
Keywords: monosubstituted simple; highly para; simple arenes; para selective ... See more keywords
Chromium-catalyzed para-selective formation of quaternary carbon centers by alkylation of benzamide derivatives
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-07069-1
Abstract: Selective creation of quaternary carbon centers has been a long-standing challenge in synthetic chemistry. We report here the chromium-catalyzed, para-selective formation of arylated quaternary carbon centers by alkylative reactions of benzamide derivatives with tertiary alkylmagnesium… read more here.
Keywords: chromium catalyzed; carbon; carbon centers; para selective ... See more keywords
Dehydrogenative homocoupling of tetrafluorobenzene on Pd(111) via para-selective C-H activation.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc01476g
Abstract: Aryl homocoupling reactions via meta- and ortho-selective C-H activation have been achieved on surfaces, but the highly important para-selective C-H activation has not been reported yet. Combined with scanning tunneling microscopy, time-of-flight secondary ion mass… read more here.
Keywords: selective activation; homocoupling tetrafluorobenzene; para selective; dehydrogenative homocoupling ... See more keywords
Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c8cc09129c
Abstract: A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields.… read more here.
Keywords: para selective; selective difluoromethylation; aromatic carbonyls; catalyzed para ... See more keywords
para-Selective hydroxylation of alkyl aryl ethers.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc06210g
Abstract: para-Selective hydroxylation of alkyl aryl ethers is established, which proceeds with a ruthenium(II) catalyst, hypervalent iodine(III) and trifluoroacetic anhydride via a radical mechanism. This protocol tolerates a wide scope of substrates and provides a facile… read more here.
Keywords: aryl ethers; hydroxylation alkyl; para selective; selective hydroxylation ... See more keywords
HFIP-promoted para-selective alkylation of anilines and phenols with tertiary alkyl bromides
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00342f
Abstract: A Hexafluoroisopropanol-promoted highly regioselective Friedel-Crafts alkylation of arenes has been developed in this study. Various arenes, including anilides, anisoles, and phenols, were compatible with the reaction, leading to the para-alkylated... read more here.
Keywords: alkylation anilines; para selective; alkylation; hfip promoted ... See more keywords