Novel indolyl linked para-substituted benzylidene-based phenyl containing thiazolidienediones and their analogs as α-glucosidase inhibitors: synthesis, in vitro, and molecular docking studies
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2112-6
Abstract: Synthesis of indolyl linked benzylidene-based para-substituted phenyl containing thiazolidinediones and acyclic analogs of isoxazolidinediones—a cyclic analog of thiazolidinedione (4a–7b) in an effort to develop novel α-glucosidase inhibitors in the management of hyperglycemia for the treatment… read more here.
Keywords: para substituted; benzylidene based; phenyl containing; glucosidase inhibitors ... See more keywords
From phenols to quinones: Thermodynamics of radical scavenging activity of para-substituted phenols.
Sign Up to like & getrecommendations! Published in 2019 at "Phytochemistry"
DOI: 10.1016/j.phytochem.2019.112077
Abstract: Radical scavenging activity and subsequent oxidation resulting in quinone products represent one of the important features of phenols occurring in plants and other biological systems. However, corresponding thermochemistry data can be still considered scarce. For… read more here.
Keywords: scavenging activity; para substituted; thermodynamics; substituted phenols ... See more keywords
Formation of 2,6-dichloro-1,4-benzoquinone from aromatic compounds after chlorination.
Sign Up to like & getrecommendations! Published in 2017 at "Water research"
DOI: 10.1016/j.watres.2016.12.005
Abstract: Halobenzoquinones are a group of disinfection byproducts formed by chlorination of certain substances in water. However, to date, the identities of halobenzoquinone precursors remain unknown. In this study, the formation of 2,6-dichloro-1,4-benzoquinone (DCBQ), a typical… read more here.
Keywords: para substituted; dichloro benzoquinone; chlorination; formation ... See more keywords
Ozonation of Para-Substituted Phenolic Compounds Yields p-Benzoquinones, Other Cyclic α,β-Unsaturated Ketones, and Substituted Catechols.
Sign Up to like & getrecommendations! Published in 2018 at "Environmental science & technology"
DOI: 10.1021/acs.est.8b00011
Abstract: Phenolic moieties are common functional groups in organic micropollutants and in dissolved organic matter, and are exposed to ozone during drinking water and wastewater ozonation. Although unsubstituted phenol is known to yield potentially genotoxic p-benzoquinone… read more here.
Keywords: para substituted; substituted phenolic; ozonation; phenolic compounds ... See more keywords
Synthesis and Polymerization of an ortho-para-Substituted Tetraalkoxy [2.2]Paracylophane-1,9-diene.
Sign Up to like & getrecommendations! Published in 2022 at "ACS macro letters"
DOI: 10.1021/acsmacrolett.2c00398
Abstract: This contribution describes the synthesis of an unsymmetrical substituted tetraalkoxy[2.2]paracylophane-1,9-diene comprised of an ortho-substituted and a para-substituted dioctyloxybenzene. (Sp)-4,5,12,15-tetraoctyloxy-[2.2]paracyclophane-1,9-diene ((Sp)-pCpd) and (Rp)-4,5,13,16-tetraoctyloxy-[2.2]paracyclophane-1,9-diene ((Rp)-pCpd) are formed as planar chiral enantiomers. Unlike other tetraalkoxy-substituted pCpds that form… read more here.
Keywords: tetraalkoxy paracylophane; substituted tetraalkoxy; paracylophane diene; para substituted ... See more keywords
Para-Substituted α-Phenyl-N-tert-butyl Nitrones: Spin-Trapping, Redox and Neuroprotective Properties
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c03907
Abstract: In this work, a series of para-substituted α-phenyl-N-tert-butyl nitrones (PBN) were studied. Their radical-trapping properties were evaluated by electron paramagnetic resonance, with 4-CF3-PBN being the fastest derivative to trap the hydroxymethyl radical (•CH2OH). The redox… read more here.
Keywords: para substituted; butyl nitrones; phenyl tert; tert butyl ... See more keywords
Para-Substituted Thiosemicarbazones as Cholinesterase Inhibitors: Synthesis, In Vitro Biological Evaluation, and In Silico Study
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c08108
Abstract: The current research reports the synthesis of 14 para-substituted thiosemicarbazone derivatives in good to excellent yields using standard procedures. Initially, 4-ethoxybenzaldehyde (1) and 4-nitrobenzaldehyde (2) were refluxed with thiosemicarbazide in the presence of acetic acid… read more here.
Keywords: cholinesterase inhibitors; silico; thiosemicarbazones cholinesterase; para ... See more keywords
Antioxidant Properties of the Artist's Conk Medicinal Mushroom, Ganoderma applanatum (Agaricomycetes), upon Cultivation with para-Substituted Phenolic Compounds and Tea Leaf Extracts.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of medicinal mushrooms"
DOI: 10.1615/intjmedmushrooms.2018026329
Abstract: In this study we elucidate antioxidative properties of the mushroom Ganoderma applanatum (Pers.) Pat. enhanced by submerged culture with para-hydroxyphenolic compounds and tea leaf extracts. The tea extract has been shown to increase to different… read more here.
Keywords: tea leaf; para substituted; ganoderma applanatum; mushroom ganoderma ... See more keywords
Antiproliferative and Antibacterial Activity of Some Para-Substituted Benzylideneacetophenones and Establishing their Structure Activity Relationship
Sign Up to like & getrecommendations! Published in 2018 at "Current Science"
DOI: 10.18520/cs/v114/i02/391-396
Abstract: We report here in-vitro antiproliferative and antibacterial activity of para -substituted benzylideneacetophenones and established their structure activity relationship to optimize para position as a biologically-oriented-synthetic target for design of small moleculebased future anticancer/antibacterial agents. Among… read more here.
Keywords: para substituted; activity para; antibacterial activity; antiproliferative antibacterial ... See more keywords