Engineered Heterochronic Parabiosis in 3D Microphysiological System for Identification of Muscle Rejuvenating Factors
Sign Up to like & getrecommendations! Published in 2020 at "Advanced Functional Materials"
DOI: 10.1002/adfm.202002924
Abstract: Exposure of a young systemic milieu reveals remarkable rejuvenation effects on aged tissues, including skeletal muscle. Although some candidate factors have been reported, the exact underlying mechanisms of putative rejuvenating factors remain elusive, mainly due… read more here.
Keywords: system; muscle; parabiosis; muscle stem ... See more keywords
A zebrafish tale of parabiosis, podocytes, and proteinuria.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.04.041
Abstract: Glomerular damage is a harbinger of kidney dysfunction. Circulating permeability factors are implicated in causing primary and secondary damage to podocytes, leading to proteinuria and eventual progression to the nephrotic syndrome, but the mechanisms are… read more here.
Keywords: methodology; podocytes proteinuria; parabiosis; tale parabiosis ... See more keywords
Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00698-y
Abstract: Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem… read more here.
Keywords: orthogonal proteome; bio orthogonal; parabiosis; chemistry ... See more keywords
Addendum: Application of bio-orthogonal proteome labeling to cell transplantation and heterochronic parabiosis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02779-4
Abstract: Studies of heterochronic parabiosis demonstrated that with age, the composition of the circulatory milieu changes in ways that broadly inhibit tissue regenerative capacity. In addition, local tissue niches have age-specific influences on their resident stem… read more here.
Keywords: orthogonal proteome; bio orthogonal; parabiosis; chemistry ... See more keywords
Molecular hallmarks of heterochronic parabiosis at single-cell resolution.
Sign Up to like & getrecommendations! Published in 2022 at "Nature"
DOI: 10.1038/s41586-022-04461-2
Abstract: The ability to slow or reverse biological ageing would have major implications for mitigating disease risk and maintaining vitality1. Although an increasing number of interventions show promise for rejuvenation2, their effectiveness on disparate cell types… read more here.
Keywords: single cell; heterochronic parabiosis; cell; parabiosis ... See more keywords
Heterochronic Parabiosis Causes Dacryoadenitis in Young Lacrimal Glands
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24054897
Abstract: Aging is associated with inflammation and oxidative stress in the lacrimal gland (LG). We investigated if heterochronic parabiosis of mice could modulate age-related LG alterations. In both males and females, there were significant increases in… read more here.
Keywords: heterochronic parabiosis; inflammation; young lgs; parabiosis ... See more keywords
Improved Bone Quality and Bone Healing of Dystrophic Mice by Parabiosis
Sign Up to like & getrecommendations! Published in 2021 at "Metabolites"
DOI: 10.3390/metabo11040247
Abstract: Duchenne muscular dystrophy (DMD) is a degenerative muscle disorder characterized by a lack of dystrophin expression in the sarcolemma of muscle fibers. DMD patients acquire bone abnormalities including osteopenia, fragility fractures, and scoliosis indicating a… read more here.
Keywords: dko mice; improved bone; parabiosis; bone ... See more keywords