Activation of parabrachial nucleus - ventral tegmental area pathway underlies the comorbid depression in chronic neuropathic pain in mice
Sign Up to like & getrecommendations! Published in 2021 at "Cell Reports"
DOI: 10.1016/j.celrep.2021.109936
Abstract: Summary Depression symptoms are often found in patients suffering from chronic pain, a phenomenon that is yet to be understood mechanistically. Here, we systematically investigate the cellular mechanisms and circuits underlying the chronic-pain-induced depression behavior.… read more here.
Keywords: chronic neuropathic; depression; tegmental area; ventral tegmental ... See more keywords
The Parabrachial Nucleus Directly Channels Spinal Nociceptive Signals to the Intralaminar Thalamic Nuclei, but Not the Amygdala
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2020.06.017
Abstract: The parabrachial nucleus (PBN) is one of the major targets of spinal projection neurons and plays important roles in pain. However, the architecture of the spinoparabrachial pathway underlying its functional role in nociceptive information processing… read more here.
Keywords: thalamic nuclei; nociceptive signals; intralaminar thalamic; parabrachial nucleus ... See more keywords
A subpopulation of projections from the parabrachial nucleus to the central amygdala mediates itch
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-08612-z
Abstract: The parabrachial nucleus (PBN) plays a crucial role in transmitting itch and affective pain signals to the brain regions such as the central amygdala (CeA). While CGRP+ PBN neurons have been implicated in itch processing,… read more here.
Keywords: cea; central amygdala; itch; pbn ... See more keywords
Leptin-inhibited neurons in the lateral parabrachial nucleus do not alter food intake or glucose balance
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2084159
Abstract: ABSTRACT The lateral parabrachial nucleus (LPBN) has been shown to be involved in the suppression of appetite at the pharmacological, optogenetic and chemogenetic levels. However, the signalling that mediates activation of these neurons in physiological… read more here.
Keywords: lpbnobr neurons; leptin; parabrachial nucleus; leptin inhibited ... See more keywords
Ethanol depresses neurons in the lateral parabrachial nucleus by potentiating pre- and postsynaptic GABAA receptors
Sign Up to like & getrecommendations! Published in 2023 at "Neuroreport"
DOI: 10.1097/wnr.0000000000001907
Abstract: As a psychoactive substance, ethanol is widely used in people’s life. However, the neuronal mechanisms underlying its sedative effect remain unclear. In this study, we investigated the effects of ethanol on the lateral parabrachial nucleus… read more here.
Keywords: lateral parabrachial; parabrachial nucleus; pre postsynaptic; lpb neurons ... See more keywords
Ultrastructure of Rat Rostral Nucleus of the Solitary Tract Terminals in the Parabrachial Nucleus and Medullary Reticular Formation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.858617
Abstract: Neurons in the rostral nucleus of the solitary tract (rNST) receive taste information from the tongue and relay it mainly to the parabrachial nucleus (PBN) and the medullary reticular formation (RF) through two functionally different… read more here.
Keywords: solitary tract; nucleus solitary; parabrachial nucleus; medullary reticular ... See more keywords
Involvement of the parabrachial nucleus in emergence from general anesthesia
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2024.1500353
Abstract: The parabrachial nucleus (PBN), located in the dorsolateral pons, is involved in many important biological functions, such as sensory signaling, feeding, defensive behaviors, fear, anxiety, and sleep–wake cycles. General anesthesia shares the classical feature of… read more here.
Keywords: emergence general; general anesthesia; anesthesia; parabrachial nucleus ... See more keywords
Changes in the excitability of the medial parabrachial nucleus neurons during the chronic phase of pilocarpine-induced epilepsy in mice
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2025.1474254
Abstract: Introduction Epilepsy is a common and serious brain disorder that often co-occurs with sleep disturbances. Sodium valproate, a conventional antiepileptic drug, alleviates sleep disorders in patients with epilepsy; however, the exact underlying mechanism remains unclear.… read more here.
Keywords: nucleus neurons; excitability medial; epilepsy; medial parabrachial ... See more keywords