UHPLC–QTOF–MS Metabolic Profiling of Marchantia polymorpha and Evaluation of Its Hepatoprotective Activity Using Paracetamol-Induced Liver Injury in Mice
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.3c01867
Abstract: Marchantia species were traditionally used to treat liver failure. Marchantia polymorpha chloroform extract showed a marked hepatoprotective activity in a dose-dependent manner in paracetamol-induced extensive liver damage in mice. At a dose of 500 mg/kg… read more here.
Keywords: hepatoprotective activity; marchantia; activity; metabolic profiling ... See more keywords
Temporal analysis of paracetamol-induced hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2022 at "Drug and chemical toxicology"
DOI: 10.1080/01480545.2022.2052891
Abstract: Paracetamol-induced hepatotoxicity (APAP) causes severe damage that may be irreversible. Understanding the evolution of liver injury caused by overdose of the drug is important to assist in the treatment. In the present study, we evaluated… read more here.
Keywords: induced hepatotoxicity; temporal analysis; analysis paracetamol; paracetamol induced ... See more keywords
Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0325782
Abstract: Background Paracetamol overdose causes severe hepatotoxicity. Sonchus oleraceus is traditionally used to treat liver disorders, but its potential against paracetamol-induced liver injury is unexplored. This work aimed to investigate the protective mechanisms of an S.… read more here.
Keywords: molecular docking; sonchus oleraceus; silico studies; hepatoprotective action ... See more keywords
Nephrocurative Effect of Parthenium hysterophorus (Carrot Grass) in Paracetamol Induced Nephrotoxicity in Rabbits.
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and molecular biology"
DOI: 10.14715/cmb/2022.68.7.6
Abstract: Parthenium hysterophorus is conventionally used to treat urinary tract infections, joint pain, and hyperglycaemia. This study evaluates the reno-curative effects of methanolic extract of P. hysterophorus (MEPH) in paracetamol-induced nephrotoxic rabbits. Thirty male rabbits were… read more here.
Keywords: hysterophorus; meph; paracetamol induced; parthenium hysterophorus ... See more keywords
The Effect of Curcumin Nanoparticles on Paracetamol-Induced Liver Injury in Male Wistar Rats.
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutical nanotechnology"
DOI: 10.2174/2211738511666230601105536
Abstract: INTRODUCTION Curcumin is a naturally occurring compound that has antioxidant properties, acts as a hepatoprotective, and lowers lipid peroxidation. However, curcumin's low solubility and bioavailability are its primary drawbacks and prevent its use as a… read more here.
Keywords: curcumin; pure curcumin; group; curcumin nanoparticles ... See more keywords
Molecular mechanism of the protective effect of adenosine triphosphate against paracetamol-induced liver toxicity in rats.
Sign Up to like & getrecommendations! Published in 2023 at "General physiology and biophysics"
DOI: 10.4149/gpb_2022055
Abstract: Toxic doses of paracetamol are also known to be close to therapeutic doses. This study aimed to biochemically investigate the protective effect of ATP against paracetamol-induced oxidative liver injury in rats and to examine the… read more here.
Keywords: paracetamol; patp; protective effect; induced liver ... See more keywords