The Critical Role of Notch1–TLR 4 Signaling in the Inflammatory and Fungicidal Activity of Macrophages Against Paracoccidioides brasiliensis Strain Pb18
Sign Up to like & getrecommendations! Published in 2017 at "Mycopathologia"
DOI: 10.1007/s11046-017-0154-4
Abstract: Paracoccidioidomycosis is a systemic mycosis of deep nature that primarily affects the lung and can spread via lymphatic and hematogenous to other organs and tissues. It is mainly caused by Paracoccidioides brasiliensis fungus which exhibits… read more here.
Keywords: receptor; strain; brasiliensis; notch1 ... See more keywords
Down-regulation of TUFM impairs host cell interaction and virulence by Paracoccidioides brasiliensis
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DOI: 10.1038/s41598-019-51540-y
Abstract: The genus Paracoccidioides consist of dimorphic fungi geographically limited to the subtropical regions of Latin America, which are responsible for causing deep systemic mycosis in humans. However, the molecular mechanisms by which Paracoccidioides spp. causes… read more here.
Keywords: cell interaction; virulence; host cell; interaction ... See more keywords
Zymosan enhances in vitro phagocyte function and the immune response of mice infected with Paracoccidioides brasiliensis.
Sign Up to like & getrecommendations! Published in 2021 at "Medical mycology"
DOI: 10.1093/mmy/myaa117
Abstract: Paracoccidioides brasiliensis is the major etiologic agent of Paracoccidioidomycosis (PCM), the most frequent human deep mycosis in Latin America. It is proposed that masking of β-glucan in P. brasiliensis cell wall is a critical virulence… read more here.
Keywords: zymosan; mice; immune response; brasiliensis ... See more keywords
TLR9 stimulation induces increase in fungicidal activity of human dendritic cells challenged with Paracoccidioides brasiliensis.
Sign Up to like & getrecommendations! Published in 2018 at "Medical mycology"
DOI: 10.1093/mmy/myx126
Abstract: Microorganisms killing by dendritic cells (DCs) is an important effector mechanism during innate immune response, as it can avoid dissemination of infection during migration of these cells toward draining lymph nodes. However, this function depends… read more here.
Keywords: increase fungicidal; fungicidal activity; induces increase; dendritic cells ... See more keywords
Effects of cytochalasin E on Paracoccidioides brasiliensis
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DOI: 10.1111/jam.14053
Abstract: To determine the effects of cytochalasin E, isolated from the extremophile fungus Aspergillus felis, on the cells of Paracoccidioides brasiliensis Pb18. read more here.
Keywords: microbiology; effects cytochalasin; cytochalasin paracoccidioides; paracoccidioides brasiliensis ... See more keywords
43 kDa Glycoprotein (gp43) from Paracoccidioides brasiliensis Induced IL-17A and PGE2 Production by Human Polymorphonuclear Neutrophils: Involvement of TLR2 and TLR4
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Immunology Research"
DOI: 10.1155/2019/1790908
Abstract: The glycoprotein gp43 is the major antigenic/diagnostic component of Paracoccidioides brasiliensis, one of the etiologic agents of paracoccidioidomycosis (PCM). Gp43 has protective roles in mice, but due to adhesive properties, this glycoprotein has also been… read more here.
Keywords: glycoprotein gp43; production; gp43; tlr2 tlr4 ... See more keywords
The Human Pathogen Paracoccidioides brasiliensis Has a Unique 1-Cys Peroxiredoxin That Localizes Both Intracellularly and at the Cell Surface
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00394
Abstract: Paracoccidioides brasiliensis is a temperature-dependent dimorphic fungus that causes systemic paracoccidioidomycosis, a granulomatous disease. The massive production of reactive oxygen species (ROS) by the host's cellular immune response is an essential strategy to restrain the… read more here.
Keywords: pathogen; cys; cys peroxiredoxin; brasiliensis ... See more keywords
Linear Epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As Vaccine Candidates
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DOI: 10.3389/fimmu.2017.00224
Abstract: Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America; Histoplasma capsulatum, Coccidioides… read more here.
Keywords: systemic mycoses; fungal agents; spp; linear epitopes ... See more keywords
Metabolic Adaptation of Paracoccidioides brasiliensis in Response to in vitro Copper Deprivation
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DOI: 10.3389/fmicb.2020.01834
Abstract: Copper is an essential micronutrient for the performance of important biochemical processes such as respiration detoxification, and uptake of metals like iron. Studies have shown that copper deprivation is a strategy used by the host… read more here.
Keywords: copper deprivation; copper; metabolic adaptation; vitro copper ... See more keywords
Beyond Melanin: Proteomics Reveals Virulence-Related Proteins in Paracoccidioides brasiliensis and Paracoccidioides lutzii Yeast Cells Grown in the Presence of L-Dihydroxyphenylalanine
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Fungi"
DOI: 10.3390/jof6040328
Abstract: Species of the genus Paracoccidioides cause a systemic infection in human patients. Yeast cells of Paracoccidioides spp. produce melanin in the presence of L-dihydroxyphenylalanine and during infection, which may impact the pathogen’s survival in the… read more here.
Keywords: presence dihydroxyphenylalanine; yeast cells; paracoccidioides lutzii; lutzii yeast ... See more keywords
Proteomic Response of Paracoccidioides brasiliensis Exposed to the Antifungal 4-Methoxynaphthalene-N-acylhydrazone Reveals Alteration in Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Fungi"
DOI: 10.3390/jof9010066
Abstract: Background: Paracoccidioidomycosis is a neglected mycosis with a high socioeconomic impact that requires long-term treatment with antifungals that have limitations in their use. The development of antifungals targeting essential proteins that are present exclusively in… read more here.
Keywords: metabolism; brasiliensis exposed; paracoccidioides brasiliensis; response paracoccidioides ... See more keywords