Intrahepatic paracrine signaling by CLCF1 ameliorates diet-induced NASH in mice.
Sign Up to like & getrecommendations! Published in 2022 at "Hepatology"
DOI: 10.1002/hep.32719
Abstract: The mammalian liver harbors heterogeneous cell types that communicate via local paracrine signaling. Recent studies have delineated the transcriptomic landscape of the liver in nonalcoholic steatohepatitis (NASH) that provides insights into liver cell heterogeneity, intercellular… read more here.
Keywords: induced nash; paracrine signaling; clcf1; diet induced ... See more keywords
Identification of a Paracrine Signaling Mechanism Linking CD34high Progenitors to the Regulation of Visceral Fat Expansion and Remodeling.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.08.092
Abstract: Accumulation of visceral (VIS) is a predictor of metabolic disorders and insulin resistance. This is due in part to the limited capacity of VIS fat to buffer lipids allowing them to deposit in insulin-sensitive tissues.… read more here.
Keywords: expansion; vis fat; high aps; identification paracrine ... See more keywords
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling
Sign Up to like & getrecommendations! Published in 2021 at "Cell Research"
DOI: 10.1038/s41422-021-00528-3
Abstract: Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression and frequent recurrence. Excessive outgrowth of pericytes in GBM governs the ecology of the perivascular niche, but their function in… read more here.
Keywords: gbm; ccr5 paracrine; ccl5; paracrine signaling ... See more keywords
Oscillating two-dimensional Ca2+ waves in cell networks with bidirectional paracrine signaling
Sign Up to like & getrecommendations! Published in 2019 at "Waves in Random and Complex Media"
DOI: 10.1080/17455030.2019.1644465
Abstract: Nonlinear excitations of Ca2+ waves are investigated in a two-dimensional cell network with bidirectional paracrine signaling, both in the longitudinal and transversal directions. The semi-discrete... read more here.
Keywords: two dimensional; ca2 waves; bidirectional paracrine; paracrine signaling ... See more keywords
The critical roles of activated stellate cells-mediated paracrine signaling, metabolism and onco-immunology in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cancer"
DOI: 10.1186/s12943-018-0815-z
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant diseases worldwide. It is refractory to conventional treatments, and consequently has a documented 5-year survival rate as low as 7%. Increasing evidence indicates that… read more here.
Keywords: immunology; pancreatic ductal; ductal adenocarcinoma; paracrine signaling ... See more keywords
A Novel 3D Osteoblast and Osteocyte Model Revealing Changes in Mineralization and Pro-osteoclastogenic Paracrine Signaling During Estrogen Deficiency
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2020.00601
Abstract: Recent in vitro studies have revealed that the mechanobiological responses of osteoblasts and osteocytes are fundamentally impaired during estrogen deficiency. However, these two-dimensional (2D) cell culture studies do not account for in vivo biophysical cues.… read more here.
Keywords: osteoblast osteocyte; estrogen; estrogen deficiency; model ... See more keywords