Classical RAS proteins are not essential for paradoxical ERK activation induced by RAF inhibitors
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DOI: 10.1073/pnas.2113491119
Abstract: Significance RAF inhibitors unexpectedly induce ERK activation in normal and oncogenic RAS tumor cells, making them unsuitable for treating RAS-driven cancers. The precise mechanism of this paradox is not fully understood but is believed to… read more here.
Keywords: paradoxical erk; erk activation; raf; raf inhibitors ... See more keywords