Parafibromin immunostainings of parathyroid tumors in clinical routine: a near-decade experience from a tertiary center
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0252-6
Abstract: The cell division cycle 73 gene is mutated in familial and sporadic forms of primary hyperparathyroidism, and the corresponding protein product parafibromin has been proposed as an adjunct immunohistochemical marker for the identification of cell… read more here.
Keywords: parafibromin; parathyroid tumors; clinical routine; atypical adenomas ... See more keywords
The roles of the tumor suppressor parafibromin in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1006400
Abstract: In this review, we discuss parafibromin protein, which is encoded by CDC73. A mutation in this gene causes hyperparathyroidism-jaw tumor (HPT-JT) syndrome, an autosomal dominant disease. CDC73 is transcriptionally downregulated by the Wilms’ tumor suppressor… read more here.
Keywords: roles tumor; cancer; parafibromin; tumor suppressor ... See more keywords