Parainfluenza virus 5 is a next‐generation vaccine vector for human infectious pathogens
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Medical Virology"
DOI: 10.1002/jmv.28622
Abstract: Parainfluenza virus 5 (PIV5) is a negative‐sense, single‐stranded RNA virus that can infect humans and many species of animals. Infection in these reservoir hosts is generally asymptomatic and has few safety concerns. Emerging evidence has… read more here.
Keywords: human infectious; parainfluenza virus; vector; vaccine vector ... See more keywords
Human parainfluenza virus surveillance in pediatric patients with lower respiratory tract infections: a special view of parainfluenza type 4.
Sign Up to like & getrecommendations! Published in 2018 at "Jornal de pediatria"
DOI: 10.1016/j.jped.2017.07.017
Abstract: OBJECTIVE Characterize the role of human parainfluenza virus and its clinical features in Brazilian children under 2 years of age presenting with acute lower respiratory tract infections. METHODS Real-time assays were used to identify strains… read more here.
Keywords: lower respiratory; human parainfluenza; respiratory tract; parainfluenza virus ... See more keywords
Peripheral blood T cells response in human parainfluenza virus-associated lower respiratory tract infection in children
Sign Up to like & getrecommendations! Published in 2020 at "Saudi Journal of Biological Sciences"
DOI: 10.1016/j.sjbs.2020.07.005
Abstract: Human Parainfluenza virus (HPIV) causes lower respiratory tract infections (LRTI) mostly in young children. Respiratory viral infections may decline T cells in circulation and display enhanced pathogenicity. This study is aimed to analyze T cells… read more here.
Keywords: lower respiratory; human parainfluenza; cd8; parainfluenza virus ... See more keywords
A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49579-y
Abstract: Ectopic protein with proper steric structure was efficiently loaded onto the envelope of the F gene-defective BC-PIV vector derived from human parainfluenza virus type 2 (hPIV2) by a reverse genetics method of recombinant virus production.… read more here.
Keywords: vector; human parainfluenza; virus type; parainfluenza virus ... See more keywords
Seroprevalence of Human Parainfluenza Virus Types 1-4 Among Healthy Children Under 5 Years of Age in Korea.
Sign Up to like & getrecommendations! Published in 2018 at "Viral Immunology"
DOI: 10.1089/vim.2017.0154
Abstract: Abstract Human parainfluenza viruses (HPIVs) are among the major causes of respiratory infections in children, worldwide, including in Korea. There are four types of HPIVs, each with different epid... read more here.
Keywords: human parainfluenza; virus types; parainfluenza virus; seroprevalence human ... See more keywords
Evaluation of a live-attenuated human parainfluenza virus type 2 vaccine in adults and children.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the Pediatric Infectious Diseases Society"
DOI: 10.1093/jpids/piac137
Abstract: We conducted a phase I clinical trial of the live-attenuated recombinant human parainfluenza virus type 2 (HPIV2) vaccine candidate rHPIV2-15C/948L/∆1724 sequentially in adults, HPIV2-seropositive children, and HPIV2-seronegative children, the target population for vaccination. rHPIV2-15C/948L/∆1724 was… read more here.
Keywords: parainfluenza virus; human parainfluenza; live attenuated; virus type ... See more keywords
Safety and Immunogenicity of an mRNA-Based Human Metapneumovirus and Parainfluenza Virus Type 3 Combined Vaccine in Healthy Adults
Sign Up to like & getrecommendations! Published in 2022 at "Open Forum Infectious Diseases"
DOI: 10.1093/ofid/ofac206
Abstract: Abstract Background Human metapneumovirus (hMPV) and parainfluenza virus type 3 (PIV3) cause respiratory tract illness in children and the elderly. No licensed vaccines are available. Methods In this phase 1, randomized, dose-ranging, first-in-human study, the… read more here.
Keywords: safety; parainfluenza virus; human metapneumovirus; mrna 1653 ... See more keywords
DNA methyltransferase inhibitor 5-azacytidine enhances neuroblastoma cell lysis by an oncolytic parainfluenza virus.
Sign Up to like & getrecommendations! Published in 2023 at "Anti-cancer drugs"
DOI: 10.1097/cad.0000000000001525
Abstract: Studies with neuroblastoma have shown that the presence of aberrant DNA epigenetic modifications mediated by DNA methyltransferases correlates with poor prognosis, making these enzymes a target for therapeutics based on synthetic epigenetic modulators such as… read more here.
Keywords: neuroblastoma cell; cell; oncolytic parainfluenza; parainfluenza virus ... See more keywords
Generation of a photocontrollable recombinant bovine parainfluenza virus type 3
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.13052
Abstract: Bovine parainfluenza virus type 3 (BPIV3) is a promising vaccine vector against various respiratory virus infections, including the human PIV3, respiratory syncytial virus, and severe acute respiratory syndrome‐coronavirus 2 infections. In this study, we combined… read more here.
Keywords: bovine parainfluenza; virus; parainfluenza virus; virus type ... See more keywords
Characterization of parainfluenza virus 5 from diarrheic piglet highlights its zoonotic potential.
Sign Up to like & getrecommendations! Published in 2022 at "Transboundary and emerging diseases"
DOI: 10.1111/tbed.14482
Abstract: Parainfluenza virus 5 (PIV5), a member of paramyxoviruses, causes respiratory and neurological infection in several animal species. Whereas information on PIV5 infection in digestive system is very scarce. Here, we successfully isolated one PIV5 strain… read more here.
Keywords: piv5 strain; virus; diarrheic piglet; piv5 ... See more keywords
A Parainfluenza Virus Vector Expressing the Respiratory Syncytial Virus (RSV) Prefusion F Protein Is More Effective than RSV for Boosting a Primary Immunization with RSV
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.01512-20
Abstract: Immune responses to RSV in infants can be reduced due to immunological immaturity and immunosuppression by RSV-specific maternal antibodies. In infants and young children, two infections with wild-type RSV typically are needed to achieve the… read more here.
Keywords: immunization; rsv; vector expressing; virus ... See more keywords