Parallel Chemistry Approach to Identify Novel Nuclear Receptor Ligands Based on the GW0742 Scaffold.
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DOI: 10.1021/acscombsci.7b00066
Abstract: We describe the parallel synthesis of novel analogs of GW0742, a peroxisome proliferator-activated receptor δ (PPARδ) agonist. For that purpose, modified reaction conditions were applied, such as a solid-phase palladium-catalyzed Suzuki coupling. In addition, tetrazole-based… read more here.
Keywords: ppar; chemistry; parallel chemistry; nuclear receptor ... See more keywords