Multicrossover Randomized Controlled Trial Designs in Alzheimer Disease
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Neurology"
DOI: 10.1002/ana.25280
Abstract: Conventional parallel group randomized controlled clinical trials (RCT) in Alzheimer's disease (AD) are too large, long, expensive and insensitive to clinical change to meet the urgent need for an effective treatment. While providing good evidence… read more here.
Keywords: alzheimer disease; parallel group; randomized controlled; crossover ... See more keywords
Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis
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DOI: 10.1016/j.eclinm.2021.101125
Abstract: Background We and others have previously demonstrated that the endothelium is a primary target of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and L-arginine has been shown to improve endothelial dysfunction. However, the effects… read more here.
Keywords: trial; parallel group; interim analysis; group ... See more keywords
Re-randomization increased recruitment and provided similar treatment estimates as parallel designs in trials of febrile neutropenia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Epidemiology"
DOI: 10.1016/j.jclinepi.2018.02.002
Abstract: Objective Re-randomization trials allow patients to be re-enrolled for multiple treatment episodes. However, it remains uncertain to what extent re-randomization improves recruitment compared to parallel group designs or whether treatment estimates might be affected. Study… read more here.
Keywords: randomization; treatment; parallel group; randomization trials ... See more keywords
Assessing individual equivalence in parallel group and crossover designs: Exact test and sample size procedures
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DOI: 10.1371/journal.pone.0269128
Abstract: The consideration of individual equivalence provides an essential alternative to average equivalence in two-group comparative studies. A common procedure for declaring individual equivalence adopts the tolerance intervals of the designated proportions of measurement differences. This… read more here.
Keywords: parallel group; assessing individual; equivalence; group crossover ... See more keywords
Comparison of Effectiveness and Safety of Immunotherapy of Warts with Intralesional Versus Subcutaneous MMR Vaccine: An Open Label Randomized, Parallel Group, Clinical Trial
Sign Up to like & getrecommendations! Published in 2022 at "Indian Journal of Dermatology"
DOI: 10.4103/ijd.ijd_960_21
Abstract: Common wart, also known as verruca vulgaris is characterized by focal proliferation of keratinocytes caused by multiple strains of human papilloma virus (HPV). Conventional treatments like chemical cautery, cryotherapy, electro-cautery, etc often fail to cure… read more here.
Keywords: parallel group; safety; mmr; group ... See more keywords