Enantioselective Excited-State Nazarov Reaction: A Relay Strategy of Electrocyclization and Parallel Kinetic Resolution.
Sign Up to like & getrecommendations! Published in 2024 at "Organic letters"
DOI: 10.1021/acs.orglett.4c04177
Abstract: We report herein the enantioselective photoinduced Nazarov reaction using a relay strategy of an electrocyclization, followed by parallel kinetic resolution (PKR). No enantioselectivity was observed during electrocyclization due to weak coordination between chiral ligands and… read more here.
Keywords: parallel kinetic; electrocyclization; nazarov reaction; relay strategy ... See more keywords
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
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DOI: 10.1038/s41587-020-0646-5
Abstract: Engineered Sp Cas9s and As Cas12a cleave fewer off-target genomic sites than wild-type (wt) Cas9. However, understanding their fidelity, mechanisms and cleavage outcomes requires systematic profiling across mispaired target DNAs. Here we describe NucleaSeq—nuclease digestion… read more here.
Keywords: cleavage; massively parallel; target; parallel kinetic ... See more keywords