Structural and biophysical insight into dual site binding of the protoberberine alkaloid palmatine to parallel G-quadruplex DNA using NMR, fluorescence and Circular Dichroism spectroscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Biochimie"
DOI: 10.1016/j.biochi.2018.02.002
Abstract: Plant derived small molecules, which interact with and stabilize G-quadruplex DNA, act as inhibitors of telomere elongation and oncogene expression in humans. The inhibition of telomerase enzyme has immense potential since it is over expressed… read more here.
Keywords: dna; quadruplex dna; nmr fluorescence; spectroscopy ... See more keywords
Highly selective recognition of intramolecular parallel G-quadruplex using a chiral supramolecular probe
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DOI: 10.1016/j.dyepig.2020.108882
Abstract: Abstract Owing to their chiral and self-assembly features, chiral supramolecules exhibit superior recognition and catalytic abilities. Here, we construct a chiral H-aggregates based on a cyanine dye, 3,3′-di(3-sulfopropyl)-4,5,4′5′-dibenzo-9-methyl-thiacarbocyanine triethylammonium salt (MeCy), by spontaneous symmetry breaking… read more here.
Keywords: parallel quadruplex; dna; quadruplex; probe ... See more keywords
Photoinduced binding of malachite green copolymer to parallel G-quadruplex DNA.
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DOI: 10.1039/c9sm00411d
Abstract: Designing ligands that selectively target G-quadruplex DNAs has gained attention due to their possible roles in regulation of gene expression and as anti-cancer agents. In this article, we report irradiation-induced ligand binding to G-quadruplex DNAs… read more here.
Keywords: photoinduced binding; quadruplex dna; malachite green; spectroscopy ... See more keywords
Properties of Parallel Tetramolecular G-Quadruplex Carrying N-Acetylgalactosamine as Potential Enhancer for Oligonucleotide Delivery to Hepatocytes
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DOI: 10.3390/molecules27123944
Abstract: The development of oligonucleotide conjugates for in vivo targeting is one of the most exciting areas for oligonucleotide therapeutics. A major breakthrough in this field was the development of multifunctional GalNAc-oligonucleotides with high affinity to… read more here.
Keywords: tetramolecular quadruplex; carrying acetylgalactosamine; parallel quadruplex; parallel tetramolecular ... See more keywords