Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments
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DOI: 10.1038/s41598-017-17692-5
Abstract: When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo… read more here.
Keywords: estimation; parallelogram based; approach; based approach ... See more keywords