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   Articles with "paralog" as a keyword



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Comprehensive prediction of robust synthetic lethality between paralog pairs in cancer cell lines.

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recommendations! Published in 2021 at "Cell systems"

DOI: 10.1016/j.cels.2021.08.006

Abstract: Pairs of paralogs may share common functionality and, hence, display synthetic lethal interactions. As the majority of human genes have an identifiable paralog, exploiting synthetic lethality between paralogs may be a broadly applicable approach for… read more here.

Keywords: cell lines; synthetic lethality; cancer; paralog ... See more keywords
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Asymmetric paralog evolution between the “cryptic” gene Bmp16 and its well-studied sister genes Bmp2 and Bmp4

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recommendations! Published in 2019 at "Scientific Reports"

DOI: 10.1038/s41598-019-40055-1

Abstract: The vertebrate gene repertoire is characterized by “cryptic” genes whose identification has been hampered by their absence from the genomes of well-studied species. One example is the Bmp16 gene, a paralog of the developmental key… read more here.

Keywords: evolution; well studied; genes bmp2; bmp16 ... See more keywords
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Engineering and functional analysis of yeast with a monotypic 40S ribosome subunit

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2114445119

Abstract: Significance Ribosomes are not monolithic but dynamic machines composed of heterogeneous ribosomal protein (RP) paralogs with elusive functions. Isolation and characterization of monotypic ribosomes with homogeneous RP paralog compositions represent ideal approaches to understand the… read more here.

Keywords: monotypic 40s; homo 40s; yeast monotypic; monotypic ... See more keywords
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A transcriptional factor B paralog functions as an activator to DNA damage-responsive expression in archaea

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recommendations! Published in 2018 at "Nucleic Acids Research"

DOI: 10.1093/nar/gky302

Abstract: Previously it was shown that UV irradiation induces a strong upregulation of tfb3 coding for a paralog of the archaeal transcriptional factor B (TFB) in Sulfolobus solfataricus, a crenarchaea. To investigate the function of this… read more here.

Keywords: dna damage; transcriptional factor; damage responsive; damage ... See more keywords
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Tup1 Paralog CgTUP11 Is a Stronger Repressor of Transcription than CgTUP1 in Candida glabrata

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recommendations! Published in 2022 at "mSphere"

DOI: 10.1128/msphere.00765-21

Abstract: Due to a whole-genome duplication, many yeast species related to C. glabrata have two copies of the well-characterized TUP1 gene, unlike most Saccharomyces species. This work identifies roles for the paralogs in C. glabrata, highlights… read more here.

Keywords: cgtup11; tup1; transcription; paralog ... See more keywords