A high‐efficient strategy for combinatorial engineering paralogous gene family: A case study on histidine kinases in Clostridium
Sign Up to like & getrecommendations! Published in 2021 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.27796
Abstract: Microorganisms harbor bulks of functionally similar or undefined genes, which belong to paralogous gene family. There is a necessity of exploring combinatorial or interactive functions of these genes, but conventional loss‐of‐function strategy with one‐by‐one rounds… read more here.
Keywords: gene family; histidine kinases; paralogous gene; strategy ... See more keywords
Structural Analysis of the Outer Membrane Lipoprotein BBA14 (OrfD) and the Corresponding Paralogous Gene Family 143 (PFam143) from Borrelia burgdorferi
Sign Up to like & getrecommendations! Published in 2022 at "Pathogens"
DOI: 10.3390/pathogens11020154
Abstract: Lyme disease is caused by the spirochete Borrelia burgdorferi, which can be transmitted to a mammalian host when infected Ixodes ticks feed. B. burgdorferi has many unique characteristics, such as the presence of at least… read more here.
Keywords: outer membrane; borrelia burgdorferi; pfam143; bba14 ... See more keywords