Simultaneous detection of intra- and inter-molecular paramagnetic relaxation enhancements in protein complexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular NMR"
DOI: 10.1007/s10858-018-0165-6
Abstract: Paramagnetic relaxation enhancement (PRE) measurements constitute a powerful approach for detecting both permanent and transient protein–protein interactions. Typical PRE experiments require an intrinsic or engineered paramagnetic site on one of the two interacting partners; while… read more here.
Keywords: detection intra; inter molecular; paramagnetic relaxation; protein complexes ... See more keywords
Impact of the Hereditary P301L Mutation on the Correlated Conformational Dynamics of Human Tau Protein Revealed by the Paramagnetic Relaxation Enhancement NMR Experiments
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DOI: 10.3390/ijms21113920
Abstract: Tau forms intracellular insoluble aggregates as a neuropathological hallmark of Alzheimer’s disease. Tau is largely unstructured, which complicates the characterization of the tau aggregation process. Recent studies have demonstrated that tau samples two distinct conformational… read more here.
Keywords: tau; paramagnetic relaxation; conformational dynamics; nmr experiments ... See more keywords