ADME: Assessing Pharmacokinetic-Pharmacodynamic Parameters of Oligonucleotides.
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DOI: 10.1007/978-1-4939-9670-4_19
Abstract: We describe tactics to assess pharmacokinetic (PK) and pharmacodynamic (PD) parameters of oligonucleotides. The chapter includes recommendations on the design of single-dose preclinical PK studies, preclinical PKPD studies, and toxicological studies, and on best practice… read more here.
Keywords: parameters oligonucleotides; pharmacodynamic parameters; assessing pharmacokinetic; biology ... See more keywords