Antiepileptic drugs: Impacts on human serum paraoxonase‐1
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.21889
Abstract: Serum paraoxonase (PON1) is a key enzyme related to high‐density lipoprotein (HDL)‐cholesterol particle. It can prevent the oxidation of low‐density lipoprotein (LDL) and HDL. The present article focuses on the in vitro inhibition role of… read more here.
Keywords: serum paraoxonase; impacts human; human serum; drugs impacts ... See more keywords
Insights into the role of paraoxonase 2 in human pathophysiology
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DOI: 10.1007/s12038-021-00234-7
Abstract: Paraoxonase 2 (PON2) is a ubiquitously expressed intracellular enzyme that is known to have a protective role from oxidative stress. Clinical studies have also demonstrated the significance of PON2 in the manifestation of cardiovascular and… read more here.
Keywords: pon2; insights role; role paraoxonase; oxidative stress ... See more keywords
Cloning, sequence analysis, and tissue expression of marmoset paraoxonase 1.
Sign Up to like & getrecommendations! Published in 2021 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2021.100398
Abstract: Paraoxonase (PON) plays roles in the metabolism of organophosphate xenobiotics and drugs. Despite the importance of marmosets for research into drug metabolism and pharmacokinetics, marmoset paraoxonase has not yet been fully characterized. Consequently, we identified… read more here.
Keywords: marmoset pon1; marmoset paraoxonase; sequence; paraoxonase ... See more keywords
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.09.237
Abstract: Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory activities of benzenesulfonamide derivatives on human paraoxonase-I… read more here.
Keywords: benzenesulfonamide derivatives; derivatives containing; activity; human paraoxonase ... See more keywords
Cardiovascular evaluation and serum paraoxonase-1 levels in adolescents with polycystic ovary syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Obstetrics and Gynaecology"
DOI: 10.1080/01443615.2019.1604643
Abstract: Abstract The aim of our study was to evaluate whether cardiovascular disease risks seen in adults with polycystic ovary syndrome (PCOS) develop in adolescents with PCOS using conventional Doppler echocardiography (CDE) and tissue Doppler echocardiography… read more here.
Keywords: polycystic ovary; pcos; group; study ... See more keywords
The role of paraoxonase and myeloperoxidase as oxidative stress markers in pregnant women with hypothyroidism
Sign Up to like & getrecommendations! Published in 2022 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2022.2114449
Abstract: Abstract Objective: This study aims to measure paraoxonase 1 (PON 1) and myeloperoxidase (MPO) levels in patients diagnosed with hypothyroidism during pregnancy by spectrophotometric method and to compare the results with healthy controls. Methods: For… read more here.
Keywords: paraoxonase; pregnant patients; oxidative stress; group ... See more keywords
Lower paraoxonase 1 paraoxonase activity is associated with a worse prognosis in patients with non-ST-segment elevation myocardial infarction in long-term follow-up
Sign Up to like & getrecommendations! Published in 2022 at "Coronary Artery Disease"
DOI: 10.1097/mca.0000000000001181
Abstract: Background Acute coronary syndrome (ACS) is one of the main manifestations of coronary artery disease, with a higher prevalence and worst prognosis. Oxidative stress is important in atherosclerosis and ACS, and paraoxonase 1 (PON1) is… read more here.
Keywords: non segment; paraoxonase; segment elevation; paraoxonase activity ... See more keywords
Serum paraoxonase 1 activity and protein N-homocysteinylation in primary human endometrial cancer
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DOI: 10.1177/1010428318797869
Abstract: Paraoxonase 1 plays an important role in protection from oxidative stress and also decomposes homocysteine thiolactone, the toxic metabolite of homocysteine. A limited number of reports evaluated the role of paraoxonase 1 in women affected… read more here.
Keywords: paraoxonase activity; homocysteine; endometrial cancer; cancer ... See more keywords
Evaluation of the prognostic value of paraoxonase 1 in the recurrence and metastasis of hepatocellular carcinoma and establishment of a liver-specific predictive model of survival
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Translational Medicine"
DOI: 10.1186/s12967-018-1707-0
Abstract: BackgroundHepatocellular carcinoma is a malignant tumor with a highly invasive and metastatic phenotype, and the detection of potential indicators associated with its recurrence and metastasis after surgical resection is critical for patient survival.MethodsTranscriptome data for… read more here.
Keywords: hepatocellular carcinoma; paraoxonase; carcinoma; recurrence metastasis ... See more keywords
Bladder Cancer Chemosensitivity Is Affected by Paraoxonase-2 Expression
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9020175
Abstract: The goal of the current study was to identify potential roles of paraoxonase-2 in bladder carcinogenesis. T24 bladder cancer cells were transfected with plasmids inducing paraoxonase-2 silencing or overexpression. Upon the selection of clones stably… read more here.
Keywords: bladder cancer; caspase; reactive oxygen; bladder ... See more keywords
Usefulness of the Measurement of Serum Paraoxonase-1 Arylesterase Activity in the Diagnoses of COVID-19
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12070879
Abstract: The development of inexpensive, fast, and reliable screening tests for COVID-19 is, as yet, an unmet need. The present study was aimed at evaluating the usefulness of serum arylesterase activity of paraoxonase-1 (PON1) measurement as… read more here.
Keywords: paraoxonase; covid; activity; arylesterase activity ... See more keywords