Indirubin-3'-monoxime induces paraptosis in MDA-MB-231 breast cancer cells by transmitting Ca2+ from endoplasmic reticulum to mitochondria.
Sign Up to like & getrecommendations! Published in 2020 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2020.108723
Abstract: PURPOSE Indirubin-3'-monoxime (I3M) induces cell death in many cancer cells; however, whether I3M regulates paraptosis is unclear. The present study aimed to investigate I3M-induced paraptosis. METHODS We treated various cancer cells with I3M, and measured… read more here.
Keywords: i3m; mda 231; paraptosis; cancer cells ... See more keywords
Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells
Sign Up to like & getrecommendations! Published in 2019 at "Redox Biology"
DOI: 10.1016/j.redox.2018.11.019
Abstract: Gastric cancer is one of the leading causes of cancer-related deaths. Chemotherapy has improved long-term survival of patients with gastric cancer. Unfortunately, cancer readily develops resistance to apoptosis-inducing agents. New mechanisms, inducing caspase-independent paraptosis-like cell… read more here.
Keywords: death; gastric cancer; paraptosis; cancer cells ... See more keywords
Paris saponin II-induced paraptosis-associated cell death increased the sensitivity of cisplatin.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2020.115206
Abstract: Paris Saponin II (PSII) has been regarded as an effective and imperative component isolated from Rhizoma Paridis saponins (RPS) and exhibited strong anti-tumor effects on a variety of cancer. Our results revealed that human non-small… read more here.
Keywords: paraptosis; paraptosis associated; induced paraptosis; cell death ... See more keywords
Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca2+ Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00061
Abstract: We previously reported that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) 4 functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand induces paraptosis, a relatively newly found programmed cell death, in cancer cells… read more here.
Keywords: membrane fusion; fusion mitochondria; paraptosis; cyclometalated iridium ... See more keywords
A Novel Insight into Paraptosis-Related Classification and Signature in Lower-Grade Gliomas
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Genomics"
DOI: 10.1155/2022/6465760
Abstract: Lower-grade gliomas (LGG) are the most common intracranial malignancies that readily evolve to high-grade gliomas and increase drug resistance. Paraptosis is defined as a nonapoptotic form of programmed cell death, which is gradually focused on… read more here.
Keywords: grade gliomas; lgg patients; paraptosis; analysis ... See more keywords
Abstract 1939: Improved activity and paraptosis-induction of anticancer thiosemicarbazones requires high copper(II) complex stability and slow reduction kinetics
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1939
Abstract: Triapine, which is currently tested in a clinical phase III trial, is the best-studied thiosemicarbazone (TSC) for anticancer therapy. With regard to the mode of action, anticancer activity of TSCs is frequently linked to their… read more here.
Keywords: stability; copper complex; copper; paraptosis ... See more keywords
Potential of Bacillus subtilis lipopeptides in anti-cancer I: induction of apoptosis and paraptosis and inhibition of autophagy in K562 cells
Sign Up to like & getrecommendations! Published in 2018 at "AMB Express"
DOI: 10.1186/s13568-018-0606-3
Abstract: The lipopeptide iturin from Bacillus subtilis has been found to have a potential inhibitory effect on breast cancer, alveolar adenocarcinoma, renal carcinoma, and colon adenocarcinoma. In this study, the potential of B. subtilis lipopeptides (a… read more here.
Keywords: apoptosis; inhibition autophagy; k562; paraptosis ... See more keywords
Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18183
Abstract: Triple negative breast cancer (TNBC) is a highly metastatic cancer among the breast cancer subgroups. A thorny issue for clinical therapy of TNBC is lack of an efficient targeted therapeutic strategy. We previously created a… read more here.
Keywords: breast cancer; paraptosis; cell death; cancer ... See more keywords
Brassinin Induces Apoptosis, Autophagy, and Paraptosis via MAPK Signaling Pathway Activation in Chronic Myelogenous Leukemia Cells
Sign Up to like & getrecommendations! Published in 2023 at "Biology"
DOI: 10.3390/biology12020307
Abstract: Simple Summary Cell death was once thought of as two distinct processes involving mainly apoptosis or necrosis. In recent years, several different forms of cell death have gained importance, such as autophagy, paraptosis, and ferroptosis.… read more here.
Keywords: signaling pathway; bsn; mapk signaling; apoptosis autophagy ... See more keywords