Loperamide overcomes the resistance of colon cancer cells to bortezomib by inducing CHOP‐mediated paraptosis‐like cell death
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2018.12.006
Abstract: &NA; Although the proteasome inhibitor (PI) bortezomib (Btz) is in current clinical use as a front‐line treatment for multiple myeloma, its clinical efficacy in solid tumors has not been satisfactory. Here, we show that loperamide… read more here.
Keywords: death; like cell; paraptosis like; colon cancer ... See more keywords
Amphiphilic Cationic Triscyclometalated Iridium(III) Complex–Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via an Intracellular Ca2+-Dependent Pathway
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c00337
Abstract: We report on the design and synthesis of a green-emitting iridium complex–peptide hybrid (IPH) 4, which has an electron-donating hydroxyacetic acid (glycolic acid) moiety between the Ir core and the peptide part. It was found… read more here.
Keywords: death; paraptosis like; cell death; complex peptide ... See more keywords
Disulfiram Oxy-Derivatives Suppress Protein Retrotranslocation across the ER Membrane to the Cytosol and Initiate Paraptosis-like Cell Death
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DOI: 10.3390/membranes12090845
Abstract: Disulfiram (DSF) and its derivatives were here investigated as antineoplastic agents, and their important feature is the ability to influence the UPS. We have recently shown that hydroxocobalamin catalyzes the aerobic oxidation of diethyldithiocarbamate to… read more here.
Keywords: paraptosis like; protein retrotranslocation; oxy derivatives; cell death ... See more keywords