Parapyruvate Induces Neurodegeneration in C57BL/6JNarl Mice via Inhibition of the α-Ketoglutarate Dehydrogenase Complex
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DOI: 10.1021/acsomega.3c09469
Abstract: Parapyruvate is a substance commonly found in commercial dietary supplements of calcium pyruvate (DSCP) that inhibits the α-ketoglutarate dehydrogenase complex (KGDHC) and has been shown to induce senescence in human Hs68 cells. However, it is… read more here.
Keywords: c57bl 6jnarl; ketoglutarate dehydrogenase; 6jnarl mice; parapyruvate ... See more keywords
Using Taguchi Method to Determine the Optimum Conditions for Synthesizing Parapyruvate
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DOI: 10.3390/molecules27061870
Abstract: The synthesis of parapyruvate is important for the analysis of the content in the pyruvate supplements and the study of aging-related neurodegenerative diseases. However, the pure parapyruvate crystal is not, as yet, commercially available. In… read more here.
Keywords: using taguchi; parapyruvate; crystallization; pure parapyruvate ... See more keywords