Integrated analysis of ceRNA‐miRNA changes in paraquat‐induced pulmonary epithelial‐mesenchymal transition via high‐throughput sequencing
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.23681
Abstract: Recent studies have shown that epithelial‐mesenchymal transition (EMT) plays an important role in paraquat (PQ)‐induced tissue fibrosis, which is the main cause of death in patients with PQ poisoning. However, no effective treatment for pulmonary… read more here.
Keywords: mesenchymal transition; paraquat induced; induced pulmonary; mirna ... See more keywords
Sodium Selenite Prevents Paraquat-Induced Neurotoxicity in Zebrafish
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0441-6
Abstract: Considering the antioxidant properties of sodium selenite (Na2SeO3) and the involvement of oxidative stress events in paraquat-induced neurotoxicity, this study investigated the protective effect of dietary Na2SeO3 on biochemical and behavioral parameters of zebrafish exposed… read more here.
Keywords: induced neurotoxicity; na2seo3 prevented; prevented increase; paraquat induced ... See more keywords
HSPB5 (αB-crystallin) confers protection against paraquat-induced oxidative stress at the organismal level in a tissue-dependent manner
Sign Up to like & getrecommendations! Published in 2020 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-020-01171-4
Abstract: Oxidative stress is one of the major and continuous stresses, an organism encounters during its lifetime. Tissues such as the brain, liver and muscles are more prone to damage by oxidative stress due to their… read more here.
Keywords: protection; induced oxidative; stress; paraquat induced ... See more keywords
Atorvastatin protected from paraquat-induced cytotoxicity in alveolar macrophages via down-regulation of TLR-4.
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2016.11.011
Abstract: The current study designed to clarify the mechanism of paraquat-induced cytotoxicity and protective effects of Atorvastatin on freshly isolated alveolar macrophages (AMs). AMs were collected via bronchoalveolar lavage and exposed to various concentrations of paraquat… read more here.
Keywords: alveolar macrophages; paraquat; tlr; induced cytotoxicity ... See more keywords
Protective effects of febuxostat against paraquat‐induced lung toxicity in rats: Impact on RAGE/PI3K/Akt pathway and downstream inflammatory cascades
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.02.007
Abstract: Aims: The herbicide paraquat causes fatal lung toxicity by induction of xanthine oxidase, production of free radicals and inflammation. Febuxostat, a xanthine oxidase inhibitor and anti‐gout has recently shown anti‐inflammatory activity. Accordingly, this study was… read more here.
Keywords: paraquat; pi3k akt; induced lung; paraquat induced ... See more keywords
TLR3 is involved in paraquat‐induced acute renal injury
Sign Up to like & getrecommendations! Published in 2019 at "Life Sciences"
DOI: 10.1016/j.lfs.2019.03.029
Abstract: Aims To investigate the role of Toll‐like receptor 3 (TLR3) in mouse paraquat‐induced acute renal injury. Materials and methods Acute renal injury was established in C57BL/6J mice by intraperitoneal injection of paraquat (28 mg/kg). The… read more here.
Keywords: paraquat; renal tissues; acute renal; renal injury ... See more keywords
Snake Venom-Inspired Novel Peptides Protect Caenorhabditis elegans against Paraquat-Induced Parkinson's Pathology.
Sign Up to like & getrecommendations! Published in 2025 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.4c00576
Abstract: The in vivo protective mechanisms of two low-molecular-mass (∼1.4 kDa) novel custom peptides (CPs) against paraquat-induced neurodegenerative dysfunction in the Caenorhabditis elegans model were deciphered. CPs prevented the paraquat from binding to the nerve ring… read more here.
Keywords: snake venom; pathology; caenorhabditis elegans; paraquat induced ... See more keywords
Cromolyn Sodium Attenuates Paraquat-Induced Lung Injury by Modulation of Proinflammatory Cytokines.
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DOI: 10.1055/s-0042-123711
Abstract: The current study aimed to investigate the effects of Cromolyn Sodium (CS) on proinflammatory cytokines in Paraquat (PQ)-induced lung damage in rat. Animals were randomly divided into 5 groups. Group 1 and 2 received nebulized… read more here.
Keywords: proinflammatory cytokines; cromolyn sodium; induced lung; paraquat induced ... See more keywords
The Ameliorative Effects of Allopurinol on Paraquat-Induced Pulmonary Fibrosis in Rats
Sign Up to like & getrecommendations! Published in 2019 at "Pharmaceutical Sciences"
DOI: 10.15171/ps.2019.2
Abstract: Background: Pulmonary fibrosis is described as a chronic idiopathic inflammatory disease of the interstitial lungs. It is associated with a potentially fatal prognosis, and patients show insignificant response to treatment. To treat paraquat (PQ)-induced pulmonary… read more here.
Keywords: fibrosis; pulmonary fibrosis; paraquat induced; effects allopurinol ... See more keywords
Effect of cyanocobalamin (vitamin B12) on paraquat-induced brain injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2022.64164.14128
Abstract: Objective(s): The goal of this study was to evaluate the neuroprotective effects of vit B12 on paraquat-induced neurotoxicity. Materials and Methods: Thirty-six male mice were randomly divided into six groups. Three groups were treated intraperitoneally… read more here.
Keywords: b12 paraquat; paraquat induced; vit b12; b12 ... See more keywords
Combined Ubisol-Q10 and Ashwagandha Root Extract Target Multiple Biochemical Mechanisms and Reduces Neurodegeneration in a Paraquat-Induced Rat Model of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Antioxidants"
DOI: 10.3390/antiox10040563
Abstract: Parkinson’s disease (PD) is characterized by progressive neurodegeneration in the substantia nigra (SN) region resulting in loss of movement coordination. Current therapies only provide symptomatic relief, and there is no agent to halt the progression… read more here.
Keywords: induced rat; treatment; ubisol q10; parkinson disease ... See more keywords