Early Postnatal Exposure to Paraquat and Maneb in Mice Increases Nigrostriatal Dopaminergic Susceptibility to a Re-challenge with the Same Pesticides at Adulthood: Implications for Parkinson’s Disease
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DOI: 10.1007/s12640-019-00097-9
Abstract: Exposure to environmental contaminants represents an important etiological factor in sporadic Parkinson’s disease (PD). It has been reported that PD could arise from events that occur early in development and that lead to delayed adverse… read more here.
Keywords: nigrostriatal dopaminergic; paraquat maneb; exposure; early postnatal ... See more keywords
Lesion of the Locus Coeruleus Damages Learning and Memory Performance in Paraquat and Maneb-induced Mouse Parkinson’s Disease Model
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DOI: 10.1016/j.neuroscience.2019.09.006
Abstract: The damage of locus coeruleus (LC) noradrenergic neurons and associated with norepinephrine (NE) depletion are early events in Parkinson's disease (PD). Previous study showed that LC/NE neurodegeneration exacerbates dopaminergic neurotoxicity and motor deficits. However, whether… read more here.
Keywords: paraquat maneb; maneb induced; induced mouse; learning memory ... See more keywords
Mechanisms Mediating the Combined Toxicity of Paraquat and Maneb in SH-SY5Y Neuroblastoma Cells
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DOI: 10.1021/acs.chemrestox.3c00389
Abstract: Epidemiological and experimental studies have demonstrated that combined exposure to the pesticides paraquat (PQ) and maneb (MB) increases the risk of developing Parkinson’s disease. However, the mechanisms mediating the toxicity induced by combined exposure to… read more here.
Keywords: sy5y neuroblastoma; toxicity; mechanisms mediating; paraquat maneb ... See more keywords