Platelets kill circulating parasites of all major Plasmodium species in human malaria.
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DOI: 10.1182/blood-2018-05-849307
Abstract: Platelets are understood to assist host innate immune responses against infection, although direct evidence of this function in any human disease, including malaria, is unknown. Here we characterized platelet-erythrocyte interactions by microscopy and flow cytometry… read more here.
Keywords: plasmodium species; parasite killing; circulating parasites; plasmodium ... See more keywords
Cell-autonomous Toxoplasma killing program requires Irgm2 but not its microbe vacuolar localization
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DOI: 10.26508/lsa.202000960
Abstract: Irgm2 controls Toxoplasma killing via selective recruitment of Gbp1 and Irgb6 to Toxoplasma parasitophorous vacuoles, whereas its vacuolar localization is dispensable for parasite killing. Interferon-inducible GTPases, such as immunity-related GTPases (IRGs) and guanylate-binding proteins (GBPs),… read more here.
Keywords: irgm2; parasite killing; toxoplasma; vacuolar localization ... See more keywords
Immune Mechanisms Involved in Schistosoma mansoni-Cathepsin B Vaccine Induced Protection in Mice
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DOI: 10.3389/fimmu.2018.01710
Abstract: A vaccine against schistosomiasis would contribute to a long-lasting decrease in disease spectrum and transmission. Our previous protection studies in mice using Schistosoma mansoni Cathepsin B (Sm-Cathepsin B) resulted in 59 and 60% worm burden… read more here.
Keywords: protection; vaccine; schistosoma mansoni; cathepsin ... See more keywords