Live and Let Dye: Visualizing the Cellular Compartments of the Malaria Parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Cytometry Part A"
DOI: 10.1002/cyto.a.23927
Abstract: Malaria remains one of the deadliest diseases worldwide and it is caused by the protozoan parasite Plasmodium spp. Parasite visualization is an important tool for the correct detection of malarial cases but also to understand… read more here.
Keywords: malaria parasite; parasite plasmodium; live let; let dye ... See more keywords
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology Research"
DOI: 10.1007/s00436-019-06305-x
Abstract: Antimicrobial peptides (AMPs) are important components of the vertebrate and invertebrate innate immune systems. Although AMPs are widely recognized for their broad-spectrum activity against bacteria, fungi, and viruses, their activity against protozoan parasites has not… read more here.
Keywords: parasite plasmodium; drosophila melanogaster; plasmodium falciparum; antimicrobial peptides ... See more keywords
Method for the separation of mitochondria and apicoplast from the malaria parasite Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology international"
DOI: 10.1016/j.parint.2018.12.003
Abstract: The growth and the survival of the human malaria parasite Plasmodium falciparum are critically dependent on the functions of the two organelles - the mitochondrion and the apicoplast. However, these two organelles have been known… read more here.
Keywords: malaria parasite; parasite plasmodium; separation; plasmodium falciparum ... See more keywords
Ozonide antimalarials alkylate heme in the malaria parasite Plasmodium falciparum.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00257
Abstract: The mechanism of action of ozonide antimalarials involves activation by intraparasitic iron and the formation of highly reactive carbon-centred radicals that alkylate malaria parasite proteins. Given free intraparasitic heme is generally thought to be the… read more here.
Keywords: malaria parasite; heme; parasite plasmodium; ozonide antimalarials ... See more keywords
Mediator Complex of the Malaria Parasite Plasmodium falciparum Associates with Evolutionarily Novel Subunits
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DOI: 10.1021/acsomega.2c00368
Abstract: The eukaryotic Mediator is a large and conserved multisubunit protein complex that directly contacts RNA polymerase II and impinges on multiple aspects of gene expression. The genome of the human malaria parasite Plasmodium falciparum has… read more here.
Keywords: plasmodium falciparum; malaria parasite; mediator complex; mediator ... See more keywords
Declines in prevalence alter the optimal level of sexual investment for the malaria parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2122165119
Abstract: Significance Like most human pathogens, the malaria parasite Plasmodium falciparum experiences strong selection pressure from public health interventions such as drug treatment. While most commonly studied in the context of drug targets and related pathways,… read more here.
Keywords: plasmodium falciparum; sexual investment; malaria parasite; falciparum ... See more keywords
A genome-wide map of DNA replication at single-molecule resolution in the malaria parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkad093
Abstract: Abstract The malaria parasite Plasmodium falciparum replicates via schizogony: an unusual type of cell cycle involving asynchronous replication of multiple nuclei within the same cytoplasm. Here, we present the first comprehensive study of DNA replication… read more here.
Keywords: plasmodium falciparum; malaria parasite; replication; parasite plasmodium ... See more keywords
A Phosphoinositide-Binding Protein Acts in the Trafficking Pathway of Hemoglobin in the Malaria Parasite Plasmodium falciparum
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.03239-21
Abstract: Malaria represents an enormous burden for a significant proportion of humanity and the lack of vaccines and problems with drug resistance to all antimalarials demonstrate the need to develop new therapeutics. Inhibitors of phosphoinositide metabolism… read more here.
Keywords: binding protein; parasite plasmodium; malaria parasite; plasmodium falciparum ... See more keywords
Postulated Process of Axoneme Organization in the Male Gametogenesis of Malaria Parasite Plasmodium berghei
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DOI: 10.2108/zs200064
Abstract: The ultrastructural features of axoneme organization within the cytoplasm and exflagellation were investigated in detail in microgametes of a malaria parasite, Plasmodium berghei, by electron and fluorescence microscopy. The kinetosomes (basal bodies) of the microgamete… read more here.
Keywords: malaria parasite; parasite plasmodium; plasmodium berghei; axoneme organization ... See more keywords
A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi
Sign Up to like & getrecommendations! Published in 2017 at "eLife"
DOI: 10.7554/elife.29605
Abstract: Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We… read more here.
Keywords: comparative transcriptomic; parasite plasmodium; liver; plasmodium cynomolgi ... See more keywords