Listeria monocytogenes Inoculation Impedes the Development of Brain Pathology in Experimental Cerebral Malaria by Inhibition of Parasitemia.
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DOI: 10.1021/acsinfecdis.1c00623
Abstract: Cerebral malaria (CM) is a serious central nervous system dysfunction caused by Plasmodium falciparum infection. In this study, we investigated the effect of Listeria monocytogenes (Lm) inoculation on experimental cerebral malaria (ECM) using Plasmodium berghei… read more here.
Keywords: inoculation; cerebral malaria; parasitemia; pathology ... See more keywords
Parasitemia Levels in Trypanosoma cruzi Infection in Spain, an Area Where the Disease Is Not Endemic: Trends by Different Molecular Approaches
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DOI: 10.1128/spectrum.02628-22
Abstract: Currently, molecular equipment has been introduced into many health care centers, even in low-income countries. PCR, qPCR, and loop-mediated isothermal amplification (LAMP) are becoming more accessible for the diagnosis of neglected infectious diseases. ABSTRACT Trypanosoma… read more here.
Keywords: parasitemia levels; spain; infection; sat tclamp ... See more keywords
Clinical relevance of low-density Plasmodium falciparum parasitemia in untreated febrile children: A cohort study
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DOI: 10.1371/journal.pmed.1003318
Abstract: Background Low-density (LD) Plasmodium infections are missed by standard malaria rapid diagnostic tests (standard mRDT) when the blood antigen concentration is below the detection threshold. The clinical impact of these LD infections is unknown. This… read more here.
Keywords: parasitemia; ultrasensitive qpcr; febrile children; mrdt ultrasensitive ... See more keywords
Association of TLR variants with susceptibility to Plasmodium vivax malaria and parasitemia in the Amazon region of Brazil
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DOI: 10.1371/journal.pone.0183840
Abstract: Background Plasmodium vivax malaria (Pv-malaria) is still considered a neglected disease despite an alarming number of individuals being infected annually. Malaria pathogenesis occurs with the onset of the vector-parasite-host interaction through the binding of pathogen-associated… read more here.
Keywords: malaria; susceptibility; parasitemia; vivax malaria ... See more keywords
The usefulness of C-reactive protein in predicting malaria parasitemia in a sub-Saharan African region
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DOI: 10.1371/journal.pone.0201693
Abstract: Background Malaria remains a leading cause of childhood mortality in sub-Saharan Africa. Identifying patients who are at risk for severe manifestations at presentation still remains challenging. This study examines whether a semi-quantitative test on C-Reactive… read more here.
Keywords: crp; sub saharan; reactive protein; parasitemia ... See more keywords
A portable brightfield and fluorescence microscope toward automated malarial parasitemia quantification in thin blood smears
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DOI: 10.1371/journal.pone.0266441
Abstract: Malaria is often most endemic in remote regions where diagnostic microscopy services are unavailable. In such regions, the use of rapid diagnostic tests fails to quantify parasitemia measurements which reflect the concentration of Plasmodium parasites… read more here.
Keywords: blood; thin blood; microscope; blood smears ... See more keywords
Functional changes in hemostasis during asexual and sexual parasitemia in a controlled human malaria infection
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DOI: 10.1371/journal.pone.0271527
Abstract: Decreased platelet count is an early phenomenon in asexual Plasmodium falciparum parasitemia, but its association with acute or long-term functional changes in platelets and coagulation is unknown. Moreover, the impact of gametocytemia on platelets and… read more here.
Keywords: controlled human; infection; parasitemia; platelet ... See more keywords
PfSPZ-CVac efficacy against malaria increases from 0% to 75% when administered in the absence of erythrocyte stage parasitemia: A randomized, placebo-controlled trial with controlled human malaria infection
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009594
Abstract: PfSPZ-CVac combines ‘PfSPZ Challenge’, which consists of infectious Plasmodium falciparum sporozoites (PfSPZ), with concurrent antimalarial chemoprophylaxis. In a previously-published PfSPZ-CVac study, three doses of 5.12x104 PfSPZ-CVac given 28 days apart had 100% vaccine efficacy (VE)… read more here.
Keywords: malaria; pfspz; parasitemia; day ... See more keywords
Lycopene supplementation promoted increased survival and decreased parasitemia in mice with severe malaria: comparison with N-acetylcysteine.
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DOI: 10.1590/0001-3765202420230347
Abstract: Oxidative stress is involved in the pathogenesis of malaria, causing anemia, respiratory complications, and cerebral malaria. To mitigate oxidative stress, we investigated the effect of nutritional supplementation whit lycopene (LYC) on the evolution of parasitemia… read more here.
Keywords: supplementation; survival; supplementation promoted; survival rate ... See more keywords
Quantitative PCR for parasitemia monitoring and preemptive therapy in patients with Chagas disease and autoimmune rheumatic disorders undergoing biologic treatment: a case series
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DOI: 10.1590/0037-8682-0419-2024
Abstract: ABSTRACT Patients with chronic Chagas disease (CD) and autoimmune rheumatic disorders (ARD) receiving immunosuppressive therapy are at risk for CD reactivation (CDR). This study monitored parasitemia over 9-121 months in six patients with CD and… read more here.
Keywords: therapy; autoimmune rheumatic; parasitemia; chagas disease ... See more keywords
Efficacy of the Benznidazole+Posaconazole combination therapy in parasitemia reduction: An experimental murine model of acute Chagas
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DOI: 10.1590/0037-8682-0477-2019
Abstract: Abstract INTRODUCTION: Benznidazole (BZL) and Nifurtimox (NFX) are the pharmacological treatment for acute phase Chagas Disease (CD); however, therapy resistance and residual mortality development remain important unresolved issues. Posaconazole (POS) has shown a trypanocidal effect… read more here.
Keywords: reduction; parasitemia; murine model; bzl pos ... See more keywords