PEGylated Dendritic Polyglycerol Conjugate Delivers Doxorubicin to the Parasitophorous Vacuole in Leishmania infantum Infections.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201700098
Abstract: Most drugs against visceral leishmaniasis must be administered parenterally. A controlled drug release at the target site can improve the efficacy and toxicity of antileishmanial drugs in clinical use. Amastigotes live and grow inside the… read more here.
Keywords: pegylated dendritic; conjugate; dendritic polyglycerol; parasitophorous vacuole ... See more keywords
Proteomic and structural characterization of self-assembled vesicles from excretion/secretion products of Toxoplasma gondii.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103490
Abstract: After the cell invasion, the parasite Toxoplasma gondii locates within a parasitophorous vacuole to proliferate. It continuously modifies the composition of the parasitophorous vacuole by the secretion of GRA and ROP proteins, some of which… read more here.
Keywords: secretion; secretion products; parasitophorous vacuole; toxoplasma gondii ... See more keywords
A revised mechanism for how Plasmodium falciparum recruits and exports proteins into its erythrocytic host cell
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009977
Abstract: Plasmodium falciparum exports ~10% of its proteome into its host erythrocyte to modify the host cell’s physiology. The Plasmodium export element (PEXEL) motif contained within the N-terminus of most exported proteins directs the trafficking of… read more here.
Keywords: plasmodium; exported proteins; parasitophorous vacuole; host ... See more keywords