GP63 Alters the Macrophage Golgin160-Associated PIST Distribution by Reducing Caspase-3 Expression during Leishmania major Infection.
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DOI: 10.1021/acsinfecdis.5c00531
Abstract: Leishmania major, an intracellular protozoan parasite, resides within parasitophorous vacuoles in host macrophages and relies on host-pathway manipulation for survival. Here, we uncover a novel role of the Leishmania surface metalloprotease GP63 in stabilizing the… read more here.
Keywords: parasitophorous vacuoles; leishmania major; leishmania; gp63 ... See more keywords
VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages
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DOI: 10.1371/journal.ppat.1012636
Abstract: Leishmania is a vacuolar pathogen that replicates within parasitophorous vacuoles inside host phagocytes. To promote its replication, Leishmania relies on a panoply of strategies to acquire macromolecules such as lipids from host macrophages. In this… read more here.
Keywords: parasitophorous vacuoles; host; host macrophages; endoplasmic reticulum ... See more keywords