Heparin promotes rapid fibrillation of the basic parathyroid hormone at physiological pH
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14455
Abstract: In acidic secretory granules of mammalian cells, peptide hormones including the parathyroid hormone are presumably stored in the form of functional amyloid fibrils. Mature PTH, however, is considerably positively charged in acidic environments, a condition… read more here.
Keywords: hormone; heparin promotes; promotes rapid; parathyroid hormone ... See more keywords
The pro‐sequence of parathyroid hormone prevents premature amyloid fibril formation
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Letters"
DOI: 10.1002/1873-3468.14587
Abstract: The parathyroid hormone (PTH) regulates the calcium and phosphate level in blood after secretion from parathyroid chief cells. The pre‐ and pro‐sequences of precursor preproPTH get cleaved during PTH maturation. In secretory granules, PTH forms… read more here.
Keywords: hormone; prevents premature; parathyroid; parathyroid hormone ... See more keywords
A Recombinant Parathyroid Hormone-Related Peptide Locally Applied in Osteoporotic Bone Defect.
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DOI: 10.1002/advs.202300516
Abstract: The local application of drug-loaded bioactive scaffold materials is one of the important directions to solve the clinical problem of osteoporotic (OP) bone defects. This study retains the advantages of drug loading and mechanical properties… read more here.
Keywords: bone; related peptide; osteoporotic bone; parathyroid hormone ... See more keywords
The diagnostic value of parathyroid hormone washout in primary hyperparathyroidism patients with negative or equivocal 99 m Tc‐MIBI results
Sign Up to like & getrecommendations! Published in 2019 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.24065
Abstract: The accurate identification of hyper functioning parathyroid gland is needed for definitive surgical treatment in primary hyperparathyroidism. Ultrasonography and 99mTechnetium sestamibi scintigraphy are the two most used methods with varying sensitivities. This study aimed to… read more here.
Keywords: parathyroid hormone; value parathyroid; primary hyperparathyroidism;
Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1‐34) Peptide Fragment
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DOI: 10.1002/jbmr.2917
Abstract: Polyethylene glycol (PEG) addition can prolong the pharmacokinetic and pharmacodynamic actions of a bioactive peptide in vivo, in part by impeding rates of glomerular filtration. For parathyroid hormone (PTH) peptides, pegylation could help in exploring… read more here.
Keywords: pth; pharmacodynamic actions; peptide; prolonged pharmacokinetic ... See more keywords
Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor‐Marked Stromal Population from Adipogenic to Osteoblastic Lineage
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.3811
Abstract: Intermittent parathyroid hormone (iPTH) treatment induces bone anabolic effects that result in the recovery of osteoporotic bone loss. Human PTH is usually given to osteoporotic patients because it induces osteoblastogenesis. However, the mechanism by which… read more here.
Keywords: lineage; parathyroid hormone; treatment; bone ... See more keywords
Parathyroid Hormone Therapy for Managing Chronic Hypoparathyroidism: A Systematic Review and Meta‐Analysis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4676
Abstract: The efficacy and safety of parathyroid hormone (PTH) therapy for managing long‐term hypoparathyroidism is being evaluated in ongoing clinical trials. We undertook a systematic review and meta‐analysis of currently available randomized controlled trials to investigate… read more here.
Keywords: chronic hypoparathyroidism; pth therapy; therapy; therapy managing ... See more keywords
The effect of different protease inhibitors on stability of parathyroid hormone, insulin, and prolactin levels under different lag times and storage conditions until analysis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22144
Abstract: Proteolytic cleavage through proteases affects peptide hormone levels, which is of particular significance when the time interval between sampling and analysis is prolonged. We evaluated the stability of parathyroid hormone, insulin, and prolactin molecules (i)… read more here.
Keywords: hormone; protease; parathyroid hormone; insulin prolactin ... See more keywords
Stability and validity of intact parathyroid hormone levels in different sample types and storage conditions
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23771
Abstract: Several pre‐analytical factors can affect the measurement of intact Parathyroid Hormone (IPTH). In this study, we have investigated the effects of using different types of tubes, time elapsed before separation, and storage conditions over time… read more here.
Keywords: parathyroid hormone; intact parathyroid; stability validity; storage conditions ... See more keywords
Parathyroid hormone enhances the osteo/odontogenic differentiation of dental pulp stem cells via ERK and P38 MAPK pathways
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29034
Abstract: Parathyroid hormone (PTH) is a main systemic mediator of calcium and phosphate homeostasis in the bone. Dental pulp stem cells (DPSCs) have been extensively studied in the regeneration of bone and tooth tissues. This paper… read more here.
Keywords: parathyroid hormone; odontogenic differentiation; dental pulp; pulp stem ... See more keywords
Inhibition of epidermal growth factor receptor suppresses parathyroid hormone‐related protein expression in tumours and ameliorates cancer‐associated cachexia
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12985
Abstract: Lung cancer is the primary cause of cancer deaths worldwide. Activation of epidermal growth factor receptor (EGFR) leads to lung cancer progression and poor prognosis while involuntary weight loss remains a major problem. Tumour‐derived parathyroid… read more here.
Keywords: epidermal growth; factor receptor; parathyroid hormone; growth factor ... See more keywords