Environmental chemicals and metabolic disruption in primary and secondary human parathyroid tumors.
Sign Up to like & getrecommendations! Published in 2020 at "Surgery"
DOI: 10.1016/j.surg.2020.06.010
Abstract: BACKGROUND The incidence of primary hyperparathyroidism has increased 300% in the United States in the past 30 years, and secondary hyperparathyroidism is almost universal in patients with end-stage renal disease. We assessed the presence of… read more here.
Keywords: biphenyl polychlorinated; human parathyroid; polychlorinated biphenyl; environmental chemicals ... See more keywords
Parafibromin immunostainings of parathyroid tumors in clinical routine: a near-decade experience from a tertiary center
Sign Up to like & getrecommendations! Published in 2019 at "Modern Pathology"
DOI: 10.1038/s41379-019-0252-6
Abstract: The cell division cycle 73 gene is mutated in familial and sporadic forms of primary hyperparathyroidism, and the corresponding protein product parafibromin has been proposed as an adjunct immunohistochemical marker for the identification of cell… read more here.
Keywords: parafibromin; parathyroid tumors; clinical routine; atypical adenomas ... See more keywords
Abstract 3732: Insights into the non-coding genome of parathyroid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1158/1538-7445.am2018-3732
Abstract: Background. Parathyroid tumors are characterized by genetic and epigenetic alterations resulting in aberrant expression of protein coding genes and non-coding RNAs. Although long non-coding RNAs (lncRNAs) play a regulatory role in endocrine cancer pathogenesis, a… read more here.
Keywords: insights non; coding genome; parathyroid; non coding ... See more keywords
Filamin A is reduced and contributes to the CASR sensitivity in human parathyroid tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of molecular endocrinology"
DOI: 10.1530/jme-16-0184
Abstract: Parathyroid tumors display reduced sensitivity to extracellular calcium ([Ca2+]o). [Ca2+]o activates calcium-sensing receptor (CASR), which interacts with the scaffold protein filamin A (FLNA). The study aimed to investigate: (1) the FLNA expression in human parathyroid… read more here.
Keywords: parathyroid; sensitivity; expression; casr ... See more keywords
Novel PRUNE2 Germline Mutations in Aggressive and Benign Parathyroid Neoplasms
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DOI: 10.3390/cancers15051405
Abstract: Simple Summary Recently, PRUNE2 mutations were indicated in the pathogenesis of aggressive parathyroid neoplasms. Here, we report novel, rare PRUNE2 mutations located in exons 3, 8, 9, and 12 in patients with parathyroid tumors in… read more here.
Keywords: germline; germline mutations; parathyroid tumors; parathyroid neoplasms ... See more keywords
Yes-Associated Protein 1 Is a Novel Calcium Sensing Receptor Target in Human Parathyroid Tumors
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms22042016
Abstract: The Hippo pathway is involved in human tumorigenesis and tissue repair. Here, we investigated the Hippo coactivator Yes-associated protein 1 (YAP1) and the kinase large tumor suppressor 1/2 (LATS1/2) in tumors of the parathyroid glands,… read more here.
Keywords: associated protein; yap1; sensing receptor; parathyroid tumors ... See more keywords
Parathyroid Tumors: Molecular Signatures
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DOI: 10.3390/ijms222011206
Abstract: Parathyroid tumors are rare endocrine neoplasms affecting 0.1–0.3% of the general population, including benign parathyroid adenomas (PAs; about 98% of cases), intermediate atypical parathyroid adenomas (aPAs; 1.2–1.3% of cases) and malignant metastatic parathyroid carcinomas (PCs;… read more here.
Keywords: molecular signatures; parathyroid tumors; tumors molecular;
Histone Modification on Parathyroid Tumors: A Review of Epigenetics
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23105378
Abstract: Parathyroid tumors are very prevalent conditions among endocrine tumors, being the second most common behind thyroid tumors. Secondary hyperplasia can occur beyond benign and malignant neoplasia in parathyroid glands. Adenomas are the leading cause of… read more here.
Keywords: histone modification; tumors review; parathyroid; parathyroid tumors ... See more keywords