Epitope and Paratope Mapping of PD-1/Nivolumab by Mass Spectrometry-based Hydrogen/Deuterium Exchange, Cross-linking, and Molecular Docking.
Sign Up to like & getrecommendations! Published in 2020 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.0c01291
Abstract: Programmed cell death-1 (PD-1), an antigen co-receptor on cell surfaces, is one of the conspicuous immune checkpoints. Nivolumab, a monoclonal antibody therapeutic approved by FDA, binds to PD-1 and efficiently blocks its pathways. In this… read more here.
Keywords: paratope; hydrogen deuterium; epitope paratope; cross linking ... See more keywords
Antibodies exhibit multiple paratope states influencing VH–VL domain orientations
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01319-z
Abstract: In the last decades, antibodies have emerged as one of the most important and successful classes of biopharmaceuticals. The highest variability and diversity of an antibody is concentrated on six hypervariable loops, also known as… read more here.
Keywords: paratope; exhibit multiple; paratope states; multiple paratope ... See more keywords
Prediction of Variable-Length B-Cell Epitopes for Antipeptide Paratopes Using the Program HAPTIC.
Sign Up to like & getrecommendations! Published in 2022 at "Protein and peptide letters"
DOI: 10.2174/0929866529666220203101808
Abstract: BACKGROUND B-cell epitope prediction for antipeptide antibody responses enables peptide-based vaccine design and related translational applications. This entails estimating epitope-paratope binding free-energy changes from antigen sequence; but attempts to do so assuming uniform epitope length… read more here.
Keywords: cell; antipeptide paratopes; epitope; variable length ... See more keywords