Expression of different ParE toxins results in conserved phenotypes with distinguishable classes of toxicity
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DOI: 10.1002/mbo3.902
Abstract: Toxin–antitoxin (TA) systems are found on both chromosomes and plasmids. These systems are unique in that they can confer both fatal and protective effects on bacterial cells—a quality that could potentially be harnessed given further… read more here.
Keywords: expression different; pare toxins; toxicity; exert toxicity ... See more keywords
Capability assessment of conventional and data-driven models for prediction of suspended sediment load
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DOI: 10.1007/s11356-022-18594-4
Abstract: Information about suspended sediment concentration (SSC) in the stream is vital for sustainability of water conservation and erosion control planning, designing and monitoring. In this research, prediction of SSC has been done using artificial neural… read more here.
Keywords: ann model; pare; prediction; suspended sediment ... See more keywords
Ligand-based pharmacophore modelling, in silico virtual screening, molecular docking and molecular dynamic simulation study to identify novel Francisella tularensis ParE inhibitors
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DOI: 10.1007/s11696-020-01274-3
Abstract: ParE, a subunit of topoisomerase IV, is involved in the management of DNA topology and validated to be an attractive target for the development of antibacterial agents. Availability of the crystal structure of Francisella tularensis… read more here.
Keywords: tularensis; pare inhibitors; pharmacophore modelling; tularensis pare ... See more keywords
Benzohydrazide and Phenylacetamide Scaffolds: New Putative ParE Inhibitors
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DOI: 10.3389/fbioe.2021.669728
Abstract: Antibacterial resistance (ABR) is a major life-threatening problem worldwide. Rampant dissemination of ABR always exemplified the need for the discovery of novel compounds. However, to circumvent the disease, a molecular target is required, which will… read more here.
Keywords: pare inhibitors; phenylacetamide scaffolds; benzohydrazide phenylacetamide; activity ... See more keywords
Fic Proteins Inhibit the Activity of Topoisomerase IV by AMPylation in Diverse Bacteria
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DOI: 10.3389/fmicb.2020.02084
Abstract: The Fic (filamentation induced by cyclic AMP) domain is a widely distributed motif with a conserved sequence of HPFx[D/E]GN[G/K]R, some of which regulate cellular activity by catalyzing the transfer of the AMP moiety from ATP… read more here.
Keywords: fic proteins; activity topoisomerase; diverse bacteria; activity ... See more keywords