Estimation of Circulating Drug Metabolite Exposure in Human Using In Vitro Data and Physiologically Based Pharmacokinetic Modeling: Example of a High Metabolite/Parent Drug Ratio
Sign Up to like & getrecommendations! Published in 2018 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.117.078279
Abstract: (R)-4-((4-(((4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)piperidin-1-yl)methyl)tetrahydro-2H-pyran-4-ol (TBPT), a serotonin-4 receptor partial agonist, is metabolized to two metabolites: an N-dealkylation product [(R)-3-(piperidin-4-ylmethoxy)-4-((tetrahydrofuran-3-yl)oxy)benzo[d]isoxazole (M1)] and a cyclized oxazolidine structure [7-(((4-(((R)-tetrahydrofuran-3-yl)oxy)benzo[d]isoxazol-3-yl)oxy)methyl)octahydro-3H (M2)]. After administration of TBPT to humans the exposure to M1 was… read more here.
Keywords: using vitro; ratio; parent drug; drug ... See more keywords
Editorial: Pharmacokinetic Evaluation and Modeling of Clinically Significant Drug Metabolites
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2021.693922
Abstract: Pharmacokinetic evaluations and modeling in order to correlate in vitro drug dissolution kinetics with their in vivo release and absorption kinetics, estimated from the deconvolution of their pharmacokinetic data, is known as IVIVC. IVIVC is… read more here.
Keywords: editorial pharmacokinetic; parent drug; drug; evaluation ... See more keywords