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   Articles with "parent origin" as a keyword



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Elucidation of de novo small insertion/deletion biology with parent‐of‐origin phasing

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recommendations! Published in 2020 at "Human Mutation"

DOI: 10.1002/humu.23971

Abstract: The mechanisms underlying de novo insertion/deletion (indel) genesis, such as polymerase slippage, have been hypothesized but not well characterized in the human genome. We implemented two methodological improvements, which were leveraged to dissect indel mutagenesis.… read more here.

Keywords: parent origin; insertion deletion; biology; origin phasing ... See more keywords
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Genome-Wide Identification of Allele-Specific Gene Expression in a Parent-of-Origin Specific Manner.

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recommendations! Published in 2020 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-9865-4_11

Abstract: Upon fertilization, normal endosperm and embryo development require the contribution of both the maternal and paternal genomes. However, certain genes are expressed in a parent-of-origin-dependent manner, an epigenetic phenomenon known as genomic imprinting. Despite the… read more here.

Keywords: manner; expression parent; parent origin; gene expression ... See more keywords

Partitioning Phenotypic Variance Due to Parent-of-Origin Effects Using Genomic Relatedness Matrices

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recommendations! Published in 2018 at "Behavior Genetics"

DOI: 10.1007/s10519-017-9880-0

Abstract: We propose a new method, G-REMLadp, to estimate the phenotypic variance explained by parent-of-origin effects (POEs) across the genome. Our method uses restricted maximum likelihood analysis of genome-wide genetic relatedness matrices based on individuals’ phased… read more here.

Keywords: parent origin; relatedness matrices; variance; parent ... See more keywords

Parent-of-origin specific gene expression and dispersal

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recommendations! Published in 2019 at "Current Opinion in Behavioral Sciences"

DOI: 10.1016/j.cobeha.2018.06.007

Abstract: Genes can behave in ways that are conditional upon their parent-of-origin. The best understood form of this is genomic imprinting (GI), which typically involves the silencing of a gene originating from one parent and the… read more here.

Keywords: parent origin; expression; parent; origin specific ... See more keywords

Mechanism of parent-of-origin effects revealed by multi-omic data in euro-chinese hybrid pigs

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-62243-6

Abstract: Parent-of-origin effects refer to the phenomenon whereby the gene expression and corresponding phenotype are influenced by paternal or maternal origin, and uncovering the underlying regulatory mechanisms remains a challenging task. To address this, we designed… read more here.

Keywords: origin; mechanism parent; parent origin; origin effects ... See more keywords

Parent-of-origin effects on complex traits in up to 236,781 individuals

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recommendations! Published in 2025 at "Nature"

DOI: 10.1038/s41586-025-09357-5

Abstract: Parent-of-origin effects (POEs) occur when the effect of a genetic variant depends on its parental origin1. Traditionally linked to genomic imprinting, POEs are believed to occur due to parental conflict over resource allocation to offspring,… read more here.

Keywords: complex traits; parent origin; origin effects; effects complex ... See more keywords

Parent-of-origin testing of prenatal copy number variations: a retrospective study of 167 family cases

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-86487-w

Abstract: Low-penetrance pathogenic copy number variations (CNVs), variation of uncertain significance (VUS) CNVs and likely pathogenic CNVs present a challenge for prenatal diagnosis. Previous studies have clarified the influence of a parent-of-origin test on the prenatal… read more here.

Keywords: vus cnvs; pcnvs; parent origin; cnvs ... See more keywords

Parent-of-origin differences in DNA methylation of X chromosome genes in T lymphocytes

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recommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.1910072116

Abstract: Significance Sex differences are naturally occurring disease modifiers that, if understood, could lead to novel targets for drug development. Autoimmune diseases are more prevalent in women than in men, and sex differences in immune responses… read more here.

Keywords: methylation; parent origin; expression; dna methylation ... See more keywords

Genome-wide survey of parent-of-origin effects on DNA methylation identifies candidate imprinted loci in humans

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recommendations! Published in 2018 at "Human Molecular Genetics"

DOI: 10.1093/hmg/ddy206

Abstract: Abstract Genomic imprinting is an epigenetic mechanism leading to parent-of-origin silencing of alleles. So far, the precise number of imprinted regions in humans is uncertain. In this study, we leveraged genome-wide DNA methylation in whole… read more here.

Keywords: genome wide; methylation; dna methylation; parent origin ... See more keywords

Spatial and temporal regulation of parent-of-origin allelic expression in the endosperm

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recommendations! Published in 2022 at "Plant Physiology"

DOI: 10.1093/plphys/kiac520

Abstract: Genomic imprinting promotes differential expression of parental alleles in the endosperm of flowering plants, and is regulated by epigenetic modification such as DNA methylation and histone tail modifications in chromatin. After fertilization, the endosperm develops… read more here.

Keywords: parent origin; genomic imprinting; expression; allelic expression ... See more keywords

Parent‐of‐origin effects on carcass traits in Japanese Black cattle

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recommendations! Published in 2019 at "Journal of Animal Breeding and Genetics"

DOI: 10.1111/jbg.12382

Abstract: Variances caused by the differential expression of paternally and maternally imprinted genes controlling carcass traits in Japanese Black cattle were estimated in this study. Data on marbling score (BMS), carcass weight, rib thickness, rib-eye area… read more here.

Keywords: black cattle; traits japanese; japanese black; parent origin ... See more keywords